Drug Class Detail

Drug Class HER3 (ERBB3) Antibody

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Patritumab U3-1287|AMG-888 HER3 (ERBB3) Antibody 13 Patritumab (U3-1287) is a monoclonal antibody that targets HER3 and inhibits ligand binding, potentially resulting in decreased activation of downstream signaling and reduced tumor growth (PMID: 24442032).
A3 TK-A3 HER3 (ERBB3) Antibody 13 A3 is a mouse monoclonal antibody that targets human Erbb3 (Her3), resulting in decreased ligand binding and downstream signaling, which potentially leads to reduced tumor growth (PMID: 22213458, PMID: 22889873).
MM-141 Istiratumab HER3 (ERBB3) Antibody 13 IGF1R Antibody 8 MM-141 (Istiratumab) is a monoclonal antibody, which binds to human epidermal growth factor receptor B3 (ERBB3) and the human insulin-like growth factor-1 receptor (IGF-1R), blocking ligand binding and preventing activation of PI3K/AKT signaling (NCI Drug Dictionary).
LJM716 anti-HER3 monoclonal antibody LJM716 HER3 (ERBB3) Antibody 13 LJM716 is a monoclonal antibody that targets ErbB3 (Her3) and prevents its transition into an active conformation, resulting in inhibition of ligand-dependent and ligand-independent downstream signaling and decreased tumor cell proliferation (PMID: 23928993).
CDX-3379 CDX3379|MEDI3379|KTN3379 HER3 (ERBB3) Antibody 13 CDX-3379 (KTN3379) is a monoclonal antibody that targets ERBB3 (HER3) and prevents ligand binding, which may reduce downstream signaling associated with ERBB2 (HER2) dimerization, and potentially leads to decreased cell proliferation and differentiation (NCI Drug Dictionary).
U3-1402 HER3 (ERBB3) Antibody 13 U3-1402 is an antibody drug conjugate comprised of an ERBB3 (HER3) antibody and Exatecan, which once internalized may result in apoptotic cell death (Journal of Thoracic Oncology, 12;11S2, 2017).
9F7-F11 HER3 (ERBB3) Antibody 13 9F7-F11 is a non-ligand competitive antibody targeting ERBB3 (HER3) that has enhanced binding to ERBB3 (HER3) in the presence of its ligand NRG1, which reduces downstream signaling and may inhibit growth of NRG1-expressing tumors (PMID: 28507002).
Seribantumab MM-121|SAR256212 HER3 (ERBB3) Antibody 13 Seribantumab (SAR256212) is a human monoclonal antibody that binds ERBB3 (HER3) and prevents ligand binding and heterodimerization with other ERBB family members, resulting in decreased activation of downstream signaling and potentially leading to reduced tumor growth (PMID: 26310543).
AV203 AV-203 HER3 (ERBB3) Antibody 13 AV203 is a humanized monoclonal antibody which binds ERBB3 (HER3) preventing ligand binding and heterodimer formation, which may inhibit tumor growth (Cancer Res April 15, 2012 72; 2509).
MM-111 HER2 (ERBB2) Antibody 26 HER3 (ERBB3) Antibody 13 MM-111 is a bispecific antibody that binds simultaneously to ERBB2 (HER2) and ERBB3 (HER3) which may block signaling and inhibit tumor growth (PMID: 22248472).
Duligotuzumab MEHD7945A EGFR Antibody 27 HER3 (ERBB3) Antibody 13 Duligotuzumab (MEHD7945A) is a two-in-one antibody that inhibits both ERBB3 (HER3) and EGFR signaling, resulting in greater efficacy than monospecific HER antibodies against multiple tumor models (PMID: 22014573).
GSK2849330 HER3 (ERBB3) Antibody 13 GSK2849330 is a monoclonal antibody that targets HER3 (ERBB3), potentially resulting in decreased proliferation of HER3-expressing tumors (NCI Drug Dictionary).
REGN1400 HER3 (ERBB3) Antibody 13 REGN1400 is a monoclonal antibody, which binds to epidermal growth factor receptor B3 (Her3), preventing neuregulin 1 ligand binding, thereby inhibiting PI3K/Akt signaling and hence cellular proliferation (NCI Drug Dictionary).
Molecular Profile Protein Effect Treatment Approaches