Drug Class Detail

Drug Class Hormone - Anti-estrogens

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Lasofoxifene CP 336156|CP-336,156|LAS Hormone - Anti-estrogens 16 Lasofoxifene is a selective estrogen response modulator (SERM) which binds to estrogen receptors and acts as an antagonist or agonist, and may decrease tumor growth (PMID: 11751385, PMID: 23604900).
Fulvestrant Faslodex ICI 182,780 Hormone - Anti-estrogens 16 Faslodex (fulvestrant) is a competitive inhibitor of estrogen that binds and deforms estrogen receptors, and causes inhibition of growth in cultured estrogen-sensitive breast cancer cells (NCI Drug Dictionary). Faslodex (fulvestrant) is FDA approved for use in patients with hormone receptor-positive breast cancer (FDA.gov).
Bazedoxifene Hormone - Anti-estrogens 16 Bazedoxifene is a selective estrogen receptor modulator, which improves bone health and lipid metabolism without adverse effects on breast and uterus (PMID: 15961563).
Fluoxymesterone Halotestin Androfluorene Hormone - Anti-estrogens 16 Halotestin (fluoxymesterone) is a synthetic derivative of testosterone that suppresses estrogen and can potentially result in anti-tumor activity (NCI Drug Dictionary).
AZD9496 Hormone - Anti-estrogens 16 AZD9496 is a selective degrader of estrogen receptor, which leads to growth inhibition of ER-positive tumors (NCI Drug Dictionary).
RU58668 RU 58668 Hormone - Anti-estrogens 16 RU58668 is an anti-estrogen that binds estrogen receptors and leads to increased estrogen receptor degradation, potentially resulting in decreased tumor growth (PMID: 8142294, PMID: 17909066).
SAR439859 Hormone - Anti-estrogens 16 SAR439859 is a selective estrogen receptor degrader that down-regulates ER expression and signaling, resulting in tumor cell growth inhibition (Cancer Res 2017;77(4 Suppl):Abstract nr P3-04-05).
GDC-0810 ARN-810 Hormone - Anti-estrogens 16 GDC-0810 binds to estrogen receptors and promotes their degradation, potentially resulting in decreased growth of estrogen receptor-expressing tumor cells (NCI Drug Dictionary).
H3B-5942 Hormone - Anti-estrogens 16 H3B-5942 is a selective estrogen receptor covalent antagonist, which antagonizes wild-type and mutant forms of estrogen receptor alpha, potentially resulting in decreased tumor cell proliferation and reduced tumor growth (PMID: 29991605).
LSZ 102 LSZ102 Hormone - Anti-estrogens 16 LSZ 102 is a selective estrogen receptor degrader (SERD) that prevents cell proliferation of ER-positive cells (PMID: 29562737).
Medroxyprogesterone Depo-Provera CBP-1011 Hormone - Anti-estrogens 16 Depo-Provera (medroxyprogesterone) is a synthetic progesterone derivative that acts as an anti-estrogen by binding to and activating nuclear receptors, stimulating downstream signaling and potentially resulting in decreased growth of estrogen-sensitive tumor cells (NCI Drug Dictionary).
Afimoxifene 4-Hydroxy-Tamoxifen Hormone - Anti-estrogens 16 Afimoxifene (4-hydroxy-tamoxifen) is a metabolite of tamoxifen, which binds to the estrogen receptor and acts as an antagonist in tumor cells (NCI Drug Dictionary).
H3B-6545 Hormone - Anti-estrogens 16 H3B-6545 is a Selective Estrogen Receptor Covalent Antagonist (SERCA) that targets both wild-type and mutant ESR1, and may result in antitumor activity (Cancer Res 2017;77(13 Suppl):Abstract nr DDT01-04).
Elacestrant RAD1901 Hormone - Anti-estrogens 16 Elacestrant (RAD1901) is a selective estrogen receptor degrader that down regulates ER and ER-regulated genes, resulting in anti-tumor activity (PMID: 28473534).
GDC-9545 RG6171 Hormone - Anti-estrogens 16 GDC-9545 is a selective estrogen receptor degrader (SERD) that prevents cell proliferation of ER-positive cells (NCI Drug Dictionary).
pipendoxifene ERA-923|ERA 923|ERA923 Hormone - Anti-estrogens 16 Pipendoxifene (ERA-923) is a selective estrogen receptor modulator, which potently inhibits estrogen binding to Esr1 (ER alpha) in breast cancer cells (PMID: 11595711).
Molecular Profile Protein Effect Treatment Approaches