Drug Class Detail

Drug Class IDO1 Inhibitor

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Drug Name Trade Name Synonyms Drug Classes Drug Description
LY3381916 IDO1 Inhibitor 9 Immune Checkpoint Inhibitor 99 LY3381916 inhibits indoleamine 2,3-dioxygenase 1 (IDO1) to prevent tryptophan breakdown in the tumor microenvironment, thereby activating a cytotoxic immune response against IDO1 expressing tumor cells (NCI Thesaurus).
Epacadostat INCB024360 IDO1 Inhibitor 9 Immune Checkpoint Inhibitor 99 Epacadostat (INCB024360) inhibits indoleamine 2,3-dioxygenase 1 (IDO1) to prevent tryptophan breakdown in the tumor microenvironment, thereby activating a cytotoxic immune response against IDO1 expressing tumor cells (PMID: 20197554).
NLG802 IDO1 Inhibitor 9 Immune Checkpoint Inhibitor 99 NLG802 is a prodrug of indoxomid, which inhibits indoleamine 2,3-dioxygenase 1 (IDO1) to prevent tryptophan breakdown in the tumor microenvironment, thereby activating a cytotoxic immune response against IDO1 expressing tumor cells (AACR Annual Meeting 2017, Abstract nr 4076).
Indoximod 1-methyl-d-tryptophan|D-1MT|1-MT|NLG-8189 IDO1 Inhibitor 9 Immune Checkpoint Inhibitor 99 Indoximod inhibits indoleamine 2,3-dioxygenase 1 (IDO1) to prevent tryptophan breakdown in the tumor microenvironment, thereby activating a cytotoxic immune response against IDO1 expressing tumor cells (PMID: 26033215, PMID: 17234791).
BMS-986205 BMS986205|BMS 986205|ONO-7701 IDO1 Inhibitor 9 Immune Checkpoint Inhibitor 99 BMS-986205 inhibits indoleamine 2,3-dioxygenase 1 (IDO1) to prevent tryptophan breakdown in the tumor microenvironment, thereby activating a cytotoxic immune response against IDO1 expressing tumor cells (PMID: 29167110).
BGB-5777 IDO1 Inhibitor 9 Immune Checkpoint Inhibitor 99 BGB-5777 inhibits indoleamine 2,3-dioxygenase 1 (IDO1) to prevent tryptophan breakdown in the tumor microenvironment, thereby activating a cytotoxic immune response against IDO1 expressing tumor cells (Neuro-Oncology, Volume 19, Issue suppl_4, 1 June 2017, Pages iv32).
MK-7162 IDO1 Inhibitor 9 Immune Checkpoint Inhibitor 99 MK-7162 inhibits indoleamine 2,3-dioxygenase 1 (IDO1) to prevent tryptophan breakdown in the tumor microenvironment, thereby activating a cytotoxic immune response against IDO1 expressing tumor cells (NCI Thesaurus).
KHK2455 IDO1 Inhibitor 9 Immune Checkpoint Inhibitor 99 KHK2455 is an IDO1 inhibitor, which results in reduced levels of kynurenine, leading to immune cell activation and subsequent tumor growth inhibition of cancer cells expressing IDO-1 (NCI Drug Dictionary).
GDC-0919 Navoximod NLG919|RG6078 IDO1 Inhibitor 9 Immune Checkpoint Inhibitor 99 GDC-0919 (Navoximod) inhibits indoleamine 2,3-dioxygenase 1 (IDO1) to prevent tryptophan breakdown in the tumor microenvironment, thereby activating a cytotoxic immune response against IDO1 expressing tumor cells (PMID: 25054064).
Molecular Profile Protein Effect Treatment Approaches