Drug Class Detail

Drug Class IGF-1R Inhibitor


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Drug Name Trade Name Synonyms Drug Classes Drug Description
Ganitumab AMG-479 IGF-1R Inhibitor 17 Ganitumab (AMG-479) is a recombinant antibody that binds to and inhibits IGF-1R. Inhibition of IGF-1R prevents activation of the downstream PI3K/Akt pathway, which may inhibit proliferation and induce apoptosis of tumor cells (NCI Drug Dictionary).
AZD3463 ALK Inhibitor 19 IGF-1R Inhibitor 17 ROS1 Inhibitor 14 AZD3463 inhibits IGF1R and ALK, including wild-type and mutant ALK, and has additional activity against ROS1 fusions, which decreases downstream signaling resulting in reduced tumor cell growth (PMID: 26786851, PMID: 26372962).
GSK1904529A IGF-1R Inhibitor 17 GSK1904529A inhibits IGF-IR and IR, resulting in cell-cycle arrest and decreased tumor growth (PMID: 19383820).
AXL1717 Picropodophyllin IGF-1R Inhibitor 17 AXL1717 inhibits IGF-1R, potentially leading to decreased tumor growth (PMID: 21875414).
PQ401 IGF-1R Inhibitor 17 PQ401 inhibits IGF-1R, potentially leading to decreased tumor cell growth (PMID: 16648580).
BMS-536924 IGF-1R Inhibitor 17 BMS-536924 is an ATP-competitive inhibitor of IGF-1R and IR, which induces tumor cell apoptosis and decreases tumor growth (PMID: 25897243).
GSK1838705A IGF-1R Inhibitor 17 GSK1838705A inhibits IGF-1R, potentially leading to increased apoptosis and reduced tumor growth (PMID: 25926740).
IGF-1R/AS ODN IGF-1R Inhibitor 17 IGF-1R/AS ODN is an anti-sense oligodeoxynucleotide against the Insulin-like growth factor 1 receptor (IGF1R), which when exposed to autologous tumor cells and implanted, it promotes the release of exosomes with tumor associated antigens to induce an immune based anti-tumor response (PMID: 25391690).
BI 885578 IGF-1R Inhibitor 17 BI 885578 is a dual inhibitor of insulin like growth factor-1 receptor (IGF1R) and insulin receptor (INSR) that blocks downstream signaling and leads to growth inhibition in tumor cells (PMID: 26438154).
Brigatinib Alunbrig AP26113 ALK Inhibitor 19 EGFR Inhibitor (Pan) 38 FLT3 Inhibitor 48 IGF-1R Inhibitor 17 ROS1 Inhibitor 14 Alunbrig (brigatinib) is a multi-kinase inhibitor with selected activity against ALK, ROS1 fusions, FLT3, IGF1R and mutant EGFR, potentially resulting in decreased tumor growth (PMID: 27780853). Alunbrig (brigatinib) is FDA approved for use in patients with ALK-positive non-small cell lung cancer who have progressed on or are intolerant to crizotinib (FDA.gov).
KW-2450 Aurka Inhibitors 23 Aurkb Inhibitors 17 IGF-1R Inhibitor 17 KW-2450 is a multitargeted kinase inhibitor with activity against Aurora A and B, and IGF-1R, which potentially results in decreased tumor cell growth (PMID: 26443806).
XL228 BCR-ABL Inhibitor 23 IGF-1R Inhibitor 17 SRC Inhibitor 26 XL228 inhibits multiple tyrosine kinases, including the insulin-like growth factor 1 receptor (IGF1R), Src tyrosine kinase, and Bcr-Abl tyrosine kinase, which can lead to cell growth inhibition (Mol Cancer Ther 2009;8(12 Suppl):C192).
NVP-ADW742 ADW742 IGF-1R Inhibitor 17 NVP-ADW742 is a small molecule IGF-1R inhibitor, which potentially leads to increased tumor cell apoptosis and decreased tumor growth (PMID: 16740780, PMID: 21141739).
NVP-AEW541 IGF-1R Inhibitor 17 NVP-AEW541 is a small molecule inhibitor of IGF1R that blocks IGF-I-mediated signaling, therefore inhibits tumor cell growth (PMID: 15050915).
BMS-754807 ALK Inhibitor 19 Aurka Inhibitors 23 Aurkb Inhibitors 17 IGF-1R Inhibitor 17 MET Inhibitor 50 TrkA Receptor Inhibitor 7 BMS-754807 is a multi-kinase inhibitor with activity against IGF-1R, insulin receptor, MET, ALK, TRKA, TRKB, AURKA, and AURKB, potentially resulting in decreased tumor cell proliferation (PMID: 25748921).
TAE226 FAK inhibitor 14 IGF-1R Inhibitor 17 TAE226 inhibits FAK and IGF-IR, resulting in decreased signaling pathway activation, decreased tumor cell growth and invasion, and increased cell-cycle arrest (PMID: 17431114).
Linsitinib OSI-906 IGF-1R Inhibitor 17 Linsitinib (OSI-906) is a small molecule dual inhibitor of IGF-1R and IR, which leads to decreased tumor cell proliferation (PMID: 21425998).
Molecular Profile Protein Effect Treatment Approaches
ETV6-NTRK3 gain of function IGF-1R Inhibitor Trk Receptor Inhibitor (Pan) Crizotinib Larotrectinib