Drug Class Detail

Drug Class JAK2 Inhibitor

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Dehydrocrenatidine JAK2 Inhibitor 17 Dehydrocrenatidine is a selective JAK2 inhibitor, which decreases STAT3 signaling to prevent cell proliferation (PMID: 25583084).
Go6976 FLT3 Inhibitor 48 JAK2 Inhibitor 17 PKC alpha Inhibitor 6 PKC beta Inhibitor 6 Go6976 binds and inhibits the calcium-dependent protein kinase C (PKC) isoforms, as well as Flt3, and mutant and wild-type Jak2, which may promote apoptosis and tumor regression (PMID: 8486620, PMID: 16956345).
Baricitinib LY3009104|NCB028050 JAK1 Inhibitor 8 JAK2 Inhibitor 17 Baricitinib (LY3009104) is an inhibitor of JAK1, JAK2, and TYK2 and is under investigation for treatment of RA and cancer (PMID: 20363976).
Tyrphostin B42 AG-490 EGFR Inhibitor (Pan) 38 JAK2 Inhibitor 17 Tyrphostin B42 (AG-490) is an inhibitor of EGFR and JAK2, which inhibits cell proliferation (PMID: 1676428, PMID: 8628398).
TG02 SB1317 CDK1 Inhibitor 12 CDK2 Inhibitor 16 CDK5 Inhibitor 6 CDK7 Inhibitor 9 CDK9 Inhibitor 12 FLT3 Inhibitor 48 JAK2 Inhibitor 17 TG02 is a pyrimidine-based molecule that inhibits CDK1, CDK2, CDK3, CDK5, CDK7, CDK9, JAK2, and FLT3, which results in growth inhibition in tumor cells (PMID: 21860433).
CEP-33779 JAK2 Inhibitor 17 CEP-33779 is a selective inhibitor of JAK2, which inhibits STAT3 signaling to prevent cell proliferation (PMID: 22334590).
LS104 JAK2 Inhibitor 17 LS104 is a non-ATP competitive inhibitor of JAK2 and JAK2 (V617F), which induces apoptosis (PMID: 18483305).
AJI-100 Aurka Inhibitors 23 Aurkb Inhibitors 17 JAK2 Inhibitor 17 AJI-100 is a dual-AURKA/B, JAK2 inhibitor, which prevents cell growth and induces apoptosis (PMID: 24930769, PMID: 28077684).
Repotrectinib TPX-0005 ALK Inhibitor 19 JAK2 Inhibitor 17 ROS1 Inhibitor 14 SRC Inhibitor 26 Trk Receptor Inhibitor (Pan) 23 Repotrectinib (TPX-0005) is a multi-kinase inhibitor that demonstrates strong activity against Ros1, Ntrk1/2/3, and Alk, and also inhibits Jak2 and Src family kinases, resulting in tumor cell death (PMID: 30093503).
AJI-214 Aurka Inhibitors 23 Aurkb Inhibitors 17 JAK2 Inhibitor 17 AJI-214 is a dual-AURKA/B, JAK2 inhibitor, which prevents cell growth and induces apoptosis (PMID: 24930769, PMID: 28077684).
LFM-A13 BTK inhibitor 20 JAK2 Inhibitor 17 LFM-A13 inhibits BTK, with additional activity against JAK2 and PLK, potentially resulting in increased tumor cell apoptosis (PMID: 17098432, PMID: 15196000, PMID: 10092645).
INCB16562 JAK1 Inhibitor 8 JAK2 Inhibitor 17 INCB16562 is a selective JAK1/2 inhibitor, which inhibits STAT signaling to prevent cell proliferation (PMID: 20072651).
AT9283 ABL1 Inhibitor 4 Aurka Inhibitors 23 Aurkb Inhibitors 17 JAK2 Inhibitor 17 JAK3 Inhibitor 4 AT9283 is a dual inhibitor of JAK 2 and 3 kinases, Aurora kinases A and B, and has activity against Abl T315I (PMID: 19143567).
ON044580 BCR-ABL Inhibitor 23 JAK2 Inhibitor 17 ON044580 is a non-ATP competitive inhibitor of BCR-ABL, BCR-ABL (T315I), JAK2, and JAK2(V617F), which may inhibit cell proliferation through inhibition of STAT5 signaling (PMID: 20717479).
WP1066 JAK2 Inhibitor 17 STAT3 Inhibitor 17 WP1066 is an inhibitor of JAK2, JAK2 V617F, and STAT3, which inhibits cell proliferation (PMID: 18245540, PMID: 21792892).
EC-70124 JAK2 Inhibitor 17 EC-70124 is a multi-kinase inhibitor with activity against IKBKB and JAK2 and demonstrates anti-tumor activity in cell lines and animal models (PMID: 26826115).
CHZ868 JAK2 Inhibitor 17 CHZ868 is a Type II JAK2 inhibitor, which stabilizes JAK2 in the inactive conformation resulting in decreased downstream signaling and potentially leading to decreased tumor cell growth (PMID: 26175413).
Molecular Profile Protein Effect Treatment Approaches
JAK2 P58A gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL P106L gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 N622I gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL W515S gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 K539I gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 I682D gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 R683E gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 F556V gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 V617I gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 E846D gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL W515Q gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 F537_K539delinsL gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 H538L gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 Y931C gain of function JAK Inhibitor (Pan) JAK2 Inhibitor
JAK2 C618R gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL R321W gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL T119I gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 I682G gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL S204P unknown JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 V617F gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL W515D gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 Y931F gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 L393V gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 N909K gain of function - predicted JAK Inhibitor (Pan) JAK2 Inhibitor
JAK2 V366G gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 act mut gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 N542_E543del gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL W515E gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL W515M gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 I682F gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 G417P gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 V881A gain of function - predicted JAK Inhibitor (Pan) JAK2 Inhibitor
JAK2 M483R gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 Y317H gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL W515_P518del gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL W515N gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL W515Y gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL W515R gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 R975G gain of function - predicted JAK Inhibitor (Pan) JAK2 Inhibitor
JAK2 R564Q gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 R277K gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL W515L gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive MK2206
MPL W515A gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 F694S gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 F694L gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 T108A gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 T875N gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 H574R gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 R683G gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL S505N gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 L611S gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL Y591D gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL W515T gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL T487A gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 K539L gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 R1063H gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 R938Q gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 V625F gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 R683T gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL W515H gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL S204F gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 D873N gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 M929I gain of function - predicted JAK Inhibitor (Pan) JAK2 Inhibitor
JAK2 N99S gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 I682S gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 H538_K539delinsQL gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL V285E gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL E230G gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL W515G gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 Y44C gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 R867Q gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL W515K gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 E864K gain of function - predicted JAK Inhibitor (Pan) JAK2 Inhibitor
MPL W515V gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 R683S gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL W515I gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 K607E gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 P933R gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
MPL W515F gain of function JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 H110R gain of function - predicted JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive
JAK2 G935R gain of function - predicted JAK Inhibitor (Pan) JAK2 Inhibitor