Drug Class Detail

Drug Class LAG3 Antibody

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Relatlimab BMS-986016 Immune Checkpoint Inhibitor 99 LAG3 Antibody 10 Relatlimab (BMS-986016) is a monoclonal antibody that targets LAG3 and inhibits binding of MHC II molecules to increase cytokine production by T-cells and prevent tumor growth (Journal of Clinical Oncology 35, no. 15_suppl (May 20 2017) 9520-9520).
MGD013 Immune Checkpoint Inhibitor 99 LAG3 Antibody 10 PD-L1/PD-1 antibody 48 MGD013 is an engineered antibody protein that targets both PDCD1 (PD-1) and LAG3 resulting in enhanced T-cell mediated anti-tumor immune response (Cancer Res July 15 2016 (76) (14 Supplement) 3217).
TSR-033 LAG3 Antibody 10 TSR-033 is a humanized monoclonal antibody that targets LAG3 and inhibits binding of class II MHC molecules, potentially resulting in enhanced anti-tumor immune response, particularly in combination with other agents (PMID: 30587557).
XmAb22841 CTLA4 Antibody 9 LAG3 Antibody 10 Limited information is currently available on XmAb22841, a putative CTLA4 and LAG3 bispecific antibody (Feb, 2019).
FS118 Immune Checkpoint Inhibitor 99 LAG3 Antibody 10 PD-L1/PD-1 antibody 48 FS118 is a bispecific antibody that targets both PD-1 (PDCD1) and LAG3, potentially resulting in increased anti-tumor immune response (NCI Drug Dictionary).
MK-4280 Immune Checkpoint Inhibitor 99 LAG3 Antibody 10 MK-4280 is a monoclonal antibody that targets LAG3 and inhibits binding of MHC II molecules to increase cytokine production by T-cells and prevent tumor growth (PMID: 29359507).
LAG525 Immune Checkpoint Inhibitor 99 LAG3 Antibody 10 LAG525 is a monoclonal antibody that targets LAG3 and blocks interaction with MHC class II molecules, leading to enhanced T-cell response to tumor cells and decreased tumor growth (NCI Drug Dictionary).
BI 754111 Immune Checkpoint Inhibitor 99 LAG3 Antibody 10 BI 754111 is a monoclonal antibody that targets LAG3 and inhibits binding of MHC II molecules to increase cytokine production by T-cells and prevent tumor growth (AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 4547).
REGN3767 REGN 3767 Immune Checkpoint Inhibitor 99 LAG3 Antibody 10 REGN3767 is a monoclonal antibody that targets LAG3, potentially resulting in increased anti-tumor immune response (NCI Drug Dictionary).
Sym022 Immune Checkpoint Inhibitor 99 LAG3 Antibody 10 Sym022 is a monoclonal antibody that targets LAG3 and inhibits binding of MHC II molecules to increase cytokine production by T-cells and prevent tumor growth (AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 5626).
Molecular Profile Protein Effect Treatment Approaches