Drug Class Detail

Drug Class MEK inhibitor (Pan)

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ARRY-300 MEK300 MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18 ARRY-300 is an analog of Binimetinib (MEK162) with activity against MEK1 and MEK2 (PMID: 24434059).
RO4927350 MEK inhibitor (Pan) 20 RO4927350 is a non-ATP competitive inhibitor of MEK1/2, which may result in inhibition of cell proliferation and antitumor activity (PMID: 19244124).
WX-554 MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18 WX-554 inhibits the activity of MEK1/2, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation (PMID: 27837257).
Refametinib BAY86-9766 MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18 Refametinib (BAY86-9766) is an inhibitor of MEK1 and MEK2, which prevents growth-factor mediated cell proliferation (PMID: 24204195).
BI-847325 BI 847325|BI847325 AURK Inhibitor (Pan) 11 MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18 BI-847325 is a dual pan-MEK/Aurora inhibitor, with specific activity against MEK 1 and 2, and Aurora kinases A, B, and C (PMID: 27496137).
U0126 MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18 U0126 binds and inhibits Mek1 and Mek2, which may inhibit the activation of downstream signaling targets and reduce tumor cell proliferation (PMID: 9873633).
Trametinib Mekinist GSK1120212 MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18 Mekinist (trametinib) inhibits MEK 1 and 2, which potentially leads to reduced tumor cell proliferation (PMID: 27956260). Mekinist (trametinib) is FDA approved for melanoma patients harboring BRAF V600E or BRAF V600K mutations, and in combination with Tafinlar (dabrafinib) for BRAF V600E/K-mutant melanoma, BRAF V600E- mutant non-small cell lung cancer, and BRAF V600E-mutant anaplastic thyroid cancer (FDA.gov).
RO4987655 CH4987655 MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18 RO4987655 is a dual MEK1/2 inhibitor, which blocks RAS/RAF/MEK/ERK signaling to prevent cell proliferation (PMID: 21316218).
Binimetinib Mektovi ARRY-162|ARRY-438162|MEK162 MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18 Mektovi (binimetinib) inhibits MEK1 and MEK2 resulting in inhibition of growth factor-mediated signaling and decreased tumor cell proliferation (PMID: 23587417). Mektovi (binimetinib) in combination with Braftovi (encorafenib) is FDA approved for use in patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation (FDA.gov).
Selumetinib AZD6244|ARRY-142886 MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18 Selumetinib (AZD6244) inhibits mitogen-activated protein kinase kinases (MEK or MAPK/ERK kinases) 1 and 2, which may prevent the activation of MEK1/2-dependent effector proteins and transcription factors, reducing cellular proliferation in various cancers (PMID: 27467210).
GDC-0623 MEK inhibitor (Pan) 20 GDC-0623 is a Mek1/2 inhibitor, which results in inhibition of growth factor-mediated signaling and tumor cell proliferation (PMID: 23934108, PMID: 26615130).
MSC2015103B AS703988 MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18 MSC2015103B inhibits the activity of MEK1/2 (MAP2K1/2), which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation (NCI Drug Dictionary).
AZD8330 ARRY-424704|ARRY-704 MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18 AZD8330 is a MEK1/2 inhibitor, which blocks signaling of the Ras/Raf/MEK/ERK pathway to prevent cell proliferation (PMID: 24434059).
Pimasertib AS703026|MSC1936369B MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18 Pimasertib (MSC1936369B) binds to and inhibits MEK1/2, preventing activation of downstream targets and potentially reducing tumor cell proliferation (PMID: 23587417).
SL327 SL-327 MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18 SL327 inhibits MEK1 and MEK2, potentially resulting in decreased viability and increased apoptosis of tumor cells (PMID: 10969080, PMID: 28178630).
TAK-733 TAK733 MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18 TAK-733 inhibits MEK1 and MEK2, preventing the activation of the RAS/RAF/MEK/ERK pathway, possibly inhibiting growth factor-mediated cell signaling and tumor cell proliferation (PMID: 26439693).
Cobimetinib Cotellic GDC-0973 MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18 Cotellic (cobimetinib) is an allosteric inhibitor of MEK1/2, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation (PMID: 22084396, PMID: 27956260). Cotellic (cobimetinib) is FDA approved for melanoma patients with BRAF V600E or V600K, in combination with Zelboraf (vemurafenib) (FDA.gov).
CI-1040 PD184352|PD-184352 MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18 CI-1040 (PD184352) binds and inhibits Mek1 and Mek2, which may inhibit the activation of downstream signaling targets and reduce tumor cell proliferation (PMID: 14613031).
PD-0325901 PD0325901|PD-901 MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18 PD-0325901, a derivative of CI-1040, is a pan-MEK inhibitor, which inhibits activation of MAPK/ERK resulting in decreased tumor cell proliferation (PMID: 18952427).
RO5126766 CH5126766 MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18 RAF Inhibitor (Pan) 17 RO5126766 is dual RAF-MEK1/2 inhibitor with effectiveness against both BRAF and RAS mutated cells (PMID: 25422890).
Molecular Profile Protein Effect Treatment Approaches
KRAS Q61H loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
NRAS G13X loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
MAP2K1 E120Q gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
HRAS G12R loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
KRAS Q22K loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
HRAS G12X loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
GNA11 inact mut loss of function MEK inhibitor (Pan) PKC Inhibitor (Pan) Verteporfin
BRAF Q257R gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
KRAS Q61X loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
HRAS G13C loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
MAP2K1 amp no effect MEK inhibitor (Pan) MEK1 Inhibitor
BRAF F595L unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor
BRAF V600Q unknown BRAF Inhibitor MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor RAF Inhibitor (Pan)
BRAF T599_V600insEAT gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
HRAS Q61K loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
KRAS N116S loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
BRAF L485F gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
KRAS A11_G12insGA loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
KRAS Y71H loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
NRAS S65C loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
HRAS G12F loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
KRAS Q61E loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
MAP2K1 S218D gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 D65N gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
BRAF L505H gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF V504_R506dup gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF R347* loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
NRAS Q61E loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
BRAF G469S gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF S467A gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF T599_V600insETT gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
HRAS Q61R loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
HRAS G12H loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
KRAS D33E loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
NRAS Q61K loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
KRAS G13C loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
KRAS D153V loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
NRAS T50I gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
HRAS A146T gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
BRAF G469V gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF V600L unknown BRAF Inhibitor MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor RAF Inhibitor (Pan)
GNAQ Q209L loss of function MEK inhibitor (Pan) PKC beta Inhibitor PKC Inhibitor (Pan) Verteporfin
MAP2K1 I204T gain of function MEK inhibitor (Pan) MEK1 Inhibitor
HRAS G12N loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
BRAF V600_K601delinsE gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
KRAS G12X unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
BRAF G464R gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
KRAS V14L loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
NRAS Q61L loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
BRAF L597Q gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
KRAS E62K loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
BRAF V600R gain of function BRAF Inhibitor MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor RAF Inhibitor (Pan)
MAP2K1 V60M gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 Q56P gain of function MEK inhibitor (Pan) MEK1 Inhibitor
KRAS P34L loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
NRAS Q61H loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
HRAS K117E loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
BRAF V600X gain of function - predicted BRAF Inhibitor MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor RAF Inhibitor (Pan)
BRAF G464V gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
NRAS E63K loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
HRAS G13I unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
BRAF G596R loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
MAP2K1 act mut gain of function MEK inhibitor (Pan) MEK1 Inhibitor
KRAS G60R loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
BRAF G464E gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
HRAS Q61H loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
NRAS G13A unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
HRAS Q61N loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
BRAF D594Y unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor
KRAS G12R loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
MAP2K1 K57C gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 Y130C unknown MEK inhibitor (Pan) MEK1 Inhibitor
KRAS G12V loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
KRAS Q22R loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
BRAF N486_P490del gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
KRAS Q22E loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
HRAS G12V loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
KRAS T58I loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
BRAF G596C loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
HRAS Q61Y loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
HRAS Q61G loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
MAP2K1 K59del unknown MEK inhibitor (Pan) MEK1 Inhibitor
HRAS D33N loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
BRAF T488_Q493delinsK gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF K499E gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF V600G gain of function BRAF Inhibitor MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor RAF Inhibitor (Pan)
BRAF V471F loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
KRAS A146V loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
BRAF L597V gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
HRAS G12D loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
HRAS Q61E loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
HRAS inact mut loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
BRAF D594E loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor
HRAS T58I loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
MAP2K1 F129L gain of function MEK inhibitor (Pan) MEK1 Inhibitor
KRAS G12D loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
KRAS A59G loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
MAP2K1 P306H gain of function MEK inhibitor (Pan) MEK1 Inhibitor
HRAS G12T loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
BRAF D594H loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor
KRAS V14I loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
KRAS T74P loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
NRAS G13D loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
BRAF T488_P492del gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
NRAS G12C loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
KRAS P34R loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
KRAS G12I loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
GNA11 R183C loss of function MEK inhibitor (Pan) PKC Inhibitor (Pan) Verteporfin
BRAF A598V gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
HRAS Q61T loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
HRAS Q61L loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
KRAS G12Y loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
BRAF A728V gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
NRAS G12D loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G13R loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
HRAS G12S loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
HRAS G12E loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
KRAS Q61K loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
BRAF V487_P492delinsA gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
GNAQ R183Q loss of function MEK inhibitor (Pan) PKC beta Inhibitor PKC Inhibitor (Pan) Verteporfin
BRAF L485_P490delinsY gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
HRAS G12A loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
HRAS G13R loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
MAP2K1 D67N gain of function MEK inhibitor (Pan) MEK1 Inhibitor
KRAS G12W loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
KRAS G12S loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
BRAF K601I unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
HRAS Q61W loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
KRAS G13D loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
MAP2K1 E144K gain of function MEK inhibitor (Pan) MEK1 Inhibitor
NRAS G12A loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
KRAS G10dup loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
HRAS Q61F loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
BRAF V600D gain of function BRAF Inhibitor MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor RAF Inhibitor (Pan)
BRAF L597P unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF D594A loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor
BRAF G466V loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF act mut gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF D287H loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor
HRAS Q61C loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
HRAS G13V loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
GNA11 Q209L loss of function MEK inhibitor (Pan) PKC Inhibitor (Pan) Verteporfin
MAP2K1 G128D gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
BRAF T599_V600insTT gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF D594_T599dup gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF L597R gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
HRAS G12L loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
HRAS K117R gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
KRAS Y32S loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
GNA11 R181Q loss of function - predicted MEK inhibitor (Pan) PKC Inhibitor (Pan)
BRAF P490_Q494del gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF K601E gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
MAP2K1 Q56_V60del gain of function MEK inhibitor (Pan) MEK1 Inhibitor
KRAS Y40A loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
KRAS G12C loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
KRAS G13X loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
HRAS G13X loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
NRAS T58I loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
BRAF G469R gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF G596D loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF I463S gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
MAP2K1 F53_Q58del gain of function MEK inhibitor (Pan) MEK1 Inhibitor
GNA11 R183Q loss of function - predicted MEK inhibitor (Pan) PKC Inhibitor (Pan) Verteporfin
KRAS Q61P loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
HRAS A146V gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
HRAS G12M loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
HRAS G12K loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
BRAF D594N loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor
BRAF K601T gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
KRAS K147E loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
HRAS G13S loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
NRAS G12V loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
GNAQ R183C loss of function MEK inhibitor (Pan) PKC beta Inhibitor PKC Inhibitor (Pan)
BRAF V600E/K gain of function BRAF Inhibitor MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor RAF Inhibitor (Pan)
KRAS E63K loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
KRAS Q61L loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
BRAF F468C gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
NRAS G12Y loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
BRAF L597S gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
KRAS Q61A loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
NRAS G60E loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
KRAS G12N loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
NRAS G13S loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
HRAS Q61V loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
KRAS G12L loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
NRAS G13V unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
HRAS Q61X loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
HRAS A59T gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
BRAF E586K gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
HRAS G13D loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
MAP2K1 F53L gain of function MEK inhibitor (Pan) MEK1 Inhibitor
NRAS Q61R loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
HRAS G12W loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
BRAF G469del loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
HRAS G13T loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
KRAS G12E loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
HRAS Q61I loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
NRAS Q61P loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
GNA11 F341L loss of function - predicted MEK inhibitor (Pan) PKC Inhibitor (Pan)
BRAF K601N gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF G469L unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF G596V loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
MAP2K1 T28I gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor
BRAF V600E gain of function BRAF Inhibitor MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor RAF Inhibitor (Pan)
BRAF A598_T599insV gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
NRAS Q61X loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
BRAF T599I gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
NRAS G12R loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
KRAS A146T loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
BRAF L485_P490delinsF gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
HRAS Q61P loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
GNAQ inact mut loss of function MEK inhibitor (Pan) PKC beta Inhibitor PKC Inhibitor (Pan) Verteporfin
NRAS G12N loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
NRAS G13C loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
BRAF A598_T599insARC gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF T599R gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
BRAF V600delinsYM gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
MAP2K1 R49L gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 Q58_E62del gain of function MEK inhibitor (Pan) MEK1 Inhibitor
KRAS K5N loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
MAP2K1 E203K gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 R47Q gain of function MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 S123T gain of function MEK inhibitor (Pan) MEK1 Inhibitor
KRAS G12A loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
KRAS C118S loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
HRAS G12Y loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
HRAS Q61A loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
BRAF G466R loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
HRAS Q61M loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
KRAS N116H loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
NRAS G12X loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
HRAS K117N loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
MAP2K1 L37P gain of function MEK inhibitor (Pan) MEK1 Inhibitor
BRAF V600dup gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
KRAS F28L loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
NRAS G12S loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
BRAF F247L gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
MAP2K1 F53S unknown MEK inhibitor (Pan) MEK1 Inhibitor
MAP2K1 K57N gain of function MEK inhibitor (Pan) MEK1 Inhibitor
KRAS F156L loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
BRAF G469A gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
KRAS G12F loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
BRAF T599dup gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
KRAS Q61R loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
BRAF K601Q gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
KRAS K117N loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
BRAF L485_Q494del gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
HRAS G12C loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
NRAS A146T gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
BRAF V600M gain of function - predicted BRAF Inhibitor MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor RAF Inhibitor (Pan)
HRAS G12Q loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
HRAS G12I loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)
BRAF V600K gain of function BRAF Inhibitor MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor RAF Inhibitor (Pan)
KRAS L19F loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan) AZD4785
BRAF L485_P490del gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120