Drug Class Detail

Drug Class PARP Inhibitor (Pan)

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Drug Name Trade Name Synonyms Drug Classes Drug Description
CEP-9722 PARP Inhibitor (Pan) 17 CEP-9722 inhibits PARP1 and PARP2, potentially resulting in decreased tumor growth and increased sensitivity to DNA damaging agents (PMID: 24880570, PMID: 24714082).
NU1025 PARP Inhibitor (Pan) 17 NU1025 inhibits PARP, potentially resulting in cell death in DNA-repair deficient tumor cells (PMID: 25981734, PMID: 15829966).
Talazoparib Talzenna BMN673 PARP Inhibitor (Pan) 17 Talzenna (talazoparib) is an inhibitor of PARP1 and PARP2, which prevents the DNA repair of single strand DNA breaks, thus causing the accumulation of DNA strand breaks, genomic instability and apoptosis, and leads to lethality in homologous recombination repair deficient cells (PMID: 28242752). Talzenna (talazoparib) is FDA approved for use in patients with ERBB2 (HER2)-negative breast cancer harboring deleterious or suspected deleterious germline BRCA mutations (FDA.gov).
CEP-8983 PARP Inhibitor (Pan) 17 CEP-8983 inhibits PARP1 and PARP2, potentially resulting in decreased tumor cell viability and increased sensitivity to DNA damaging agents (PMID: 24439051, PMID: 23428903).
Veliparib ABT-888 PARP Inhibitor (Pan) 17 Veliparib (ABT-888) is a PARP1 and PARP2 inhibitor, which inhibits DNA repair and induces lethality in homologous recombination deficient cells, and may enhance the sensitivity of chemotherapeutic agents (PMID: 26251615).
BGP-15 PARP Inhibitor (Pan) 17 BGP-15 is an inhibitor of PARP, potentially resulting in decreased tumor cell growth (PMID: 11931842, PMID: 22661288).
Rucaparib Rubraca AG014699|PF-01367338|CO-388|AG14447 PARP Inhibitor (Pan) 17 Rubraca (rucaparib) binds to and inhibits PARP, which may result in accumulation of DNA damage and chemosensitization of tumor cells (PMID: 17363489). Rubraca (rucaparib) is FDA approved for use in ovarian cancer patients with deleterious somatic and/or germline BRCA mutations (FDA.gov).
E7016 PARP Inhibitor (Pan) 17 E7016 is an inhibitor of PARP1 and PARP2, which results in the accumulation of DNA damage, thereby potentially resulting in increased tumor cell death and increased sensitivity to DNA damaging agents (Mol Cancer Ther 2011;10(11 Suppl):Abstract nr B185).
Pamiparib BGB-290 PARP Inhibitor (Pan) 17 Pamiparib (BGB-290) inhibits PARP1 and PARP2, potentially resulting in increased sensitivity to DNA damaging agents (AACR; 2015. Abstract nr 1651).
PJ34 PARP Inhibitor (Pan) 17 PJ34 is a small molecule that inhibits PARP, potentially resulting in increased tumor cell death (PMID: 25531448).
A-966492 PARP Inhibitor (Pan) 17 A-966492 is an inhibitor of PARP1 and PARP2, potentially resulting in increased sensitivity of tumor cells to DNA damaging agents (PMID: 20337371).
Niraparib Zejula MK4827 PARP Inhibitor (Pan) 17 Zejula (niraparib) binds and inhibits PARP, which may result in accumulation of DNA damage and apoptosis of tumor cells (PMID: 23810788). Zejula (niraparib) is FDA-approved as maintenance therapy in patients with epithelial ovarian, fallopian tube, or primary peritoneal cancer in complete or partial response to platinum-based chemotherapy (FDA.gov).
Olaparib Lynparza AZD2281|KU-0059436 PARP Inhibitor (Pan) 17 Lynparza (olaparib) binds to and inhibits PARP, resulting in inhibition of DNA repair and lethality in homologous-recombination deficient cells, and may be a sensitizing agent for chemotherapy and radiotherapy (PMID: 25028150, PMID: 24225019). Lynparza (olaparib) is FDA approved for use in patients with germline BRCA-mutated advanced ovarian cancer, germline BRCA-mutated and ERBB2 (HER2)-negative breast cancer, and advanced epithelial ovarian, fallopian tube or primary peritoneal cancer with deleterious or suspected deleterious germline or somatic BRCA mutations (FDA.gov).
E7449 2X-121 PARP Inhibitor (Pan) 17 Tankyrase Inhibitor 9 E7449 binds to and inhibits PARP1 and PARP2, as well as TNKS1 and TNKS2, potentially resulting in increased sensitivity to DNA damaging agents and decreased growth of tumor cells with defective DNA damage repair (PMID: 26513298).
AZD2461 PARP Inhibitor (Pan) 17 AZD2461 inhibits PARP1 and PARP2, resulting in decreased tumor cell growth (PMID: 27550455).
INO-1001 PARP Inhibitor (Pan) 17 INO-1001 inhibits PARP, resulting in increased sensitivity of tumor cells to radiation and chemotherapeutics (PMID: 15036647, PMID: 17628743).
ABT-767 PARP Inhibitor (Pan) 17 ABT-767 binds to and inhibits the nuclear enzymes, PARP1 and PARP2, which prevents DNA damage repair and potentially leads to apoptosis (PMID: 28247011).
Molecular Profile Protein Effect Treatment Approaches
BRCA1 K1702E loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 L631Qfs*4 loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 V1809F loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 G2609V loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 M1689R loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM S131* loss of function - predicted PARP Inhibitor (Pan)
BRCA1 G1763V loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 K1691fs loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A R693* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 G1770V loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM N765Kfs*12 loss of function - predicted PARP Inhibitor (Pan)
BRCA1 M1775R loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 Q1756fs loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 W1837C loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM L2890V loss of function - predicted PARP Inhibitor (Pan)
ARID1A R1335* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 M1689T loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 N1309Ifs*9 loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM V2424G loss of function - predicted PARP Inhibitor (Pan)
BRCA2 G2609D loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 N257Efs*19 loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 G2793R loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 P1771L loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 R2659G loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 I247Kfs*2 loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A inact mut loss of function EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 T1302del loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 L2647P loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 S1651P loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 T2722R loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 R1753T loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 G3003E loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 M1775K loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM E1666* loss of function - predicted PARP Inhibitor (Pan)
BRCA2 N136Ifs*16 loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM W57* loss of function - predicted PARP Inhibitor (Pan)
ARID1A G276* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 V1696L loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 V1688del loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 L63F loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 S1841R loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 D1739G loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 L82P loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM L2427P loss of function - predicted PARP Inhibitor (Pan)
ATM W412* loss of function - predicted PARP Inhibitor (Pan)
BRCA2 L2654P loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q372Afs*28 loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A E1596* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 E23Vfs*17 loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 D252Vfs*24 loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 D2723H loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 Q1756* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM R2849* loss of function - predicted PARP Inhibitor (Pan)
BRCA1 T1691I loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 C64G loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 H1686R loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 I605fs loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A R1989* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 R2659K loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A S664* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 Q94* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A K1071fs loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 G2596R loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A R1528* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 loss loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM I1681V loss of function PARP Inhibitor (Pan)
BRCA1 F1704S loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 S72R loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A T294Pfs*69 loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 D2611G loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM I1849fs loss of function - predicted PARP Inhibitor (Pan)
BRCA2 D2723A loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 K45T loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A L2009_L2017del loss of function EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM T2666A loss of function - predicted PARP Inhibitor (Pan)
BRCA2 I1977fs loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM R1730* loss of function - predicted PARP Inhibitor (Pan)
BRCA1 L1705P loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A G925* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A P16_P17dup loss of function EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q1334_R1335insQ loss of function EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 L2688P loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 A1843T loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 L1657P loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 T1691K loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 L2721H loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 G2596E loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 V1741G loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 S59R loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 T256Kfs*19 loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 S1715C loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 D3095E loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A S1248* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 R1699Q loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 C1200fs loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 G1803A loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 V1713fs loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 C1697R loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 T826K loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 F1734L loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 D2723G loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 A75P loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 G1738R loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 V1810G loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A G1848fs loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 L1764P loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 R2842C loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 V1736A loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A R1446* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 R2659T loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 H41R loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 C47F loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM R2598* loss of function - predicted PARP Inhibitor (Pan)
BRCA2 F1182fs loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 I2627F loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 E1382del loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q456* loss of function EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 K45N loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM K1410* loss of function - predicted PARP Inhibitor (Pan)
ATM S2407* loss of function - predicted PARP Inhibitor (Pan)
ARID1A D1838* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q479* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A R1276* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 D244Efs*10 loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 G1706E loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 inact mut loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM K2756* loss of function - predicted PARP Inhibitor (Pan)
BRCA2 Y2726C loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 E897* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 A248Sfs*15 loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 Y1703S loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 L2792P loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 A1689fs loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM G2083* loss of function - predicted PARP Inhibitor (Pan)
ATM R3008C loss of function - predicted PARP Inhibitor (Pan)
ATM T2902fs loss of function - predicted PARP Inhibitor (Pan)
BRCA2 L2510P loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A S769* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 W1782* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 G1738E loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 S1655fs loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 D2723V loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q1095* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q1401* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 N1784fs loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A E992* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 H2623R loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 Y3092S loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 S1655F loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q790* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 W1837R loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 N3124I loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q1172* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 G2812E loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 W1718C loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 T37R loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 R2784W loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM S1455R loss of function PARP Inhibitor (Pan)
ATM E1072* loss of function - predicted PARP Inhibitor (Pan)
BRCA1 A1752V loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM L804fs loss of function - predicted PARP Inhibitor (Pan)
BRCA1 T1685I loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 L1795Pfs*3 loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM V2119fs loss of function - predicted PARP Inhibitor (Pan)
BRCA2 S2691F loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 C47G loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q528* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 E2663V loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 S3133* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM K468fs loss of function - predicted PARP Inhibitor (Pan)
ATM R337S loss of function PARP Inhibitor (Pan)
BRCA1 I1318Lfs*7 loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A G1450fs loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 Y179C loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q878* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q1479* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 G3076E loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A P224fs loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 M1628V no effect - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 N682* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 S1503* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 W1718S loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 E3002K loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM N1650S loss of function PARP Inhibitor (Pan)
BRCA1 R1699W loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 Q2655R loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 R2336H loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q1131* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 I21V unknown PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 del loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 V1736G loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Y592* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 S1064* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 D3073G loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 R3007G loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM R2993* loss of function - predicted PARP Inhibitor (Pan)
ARID1A Q708* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A S705fs loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 P2800S loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 D1739V loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 N255Tfs*21 loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 E1285fs loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM E390* loss of function - predicted PARP Inhibitor (Pan)
BRCA1 S1164I loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q1856* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 C39Y loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 E33A loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 R1203* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM S1403fs loss of function - predicted PARP Inhibitor (Pan)
BRCA2 A2786P loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q944* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM A1742P loss of function - predicted PARP Inhibitor (Pan)
ATM R250* loss of function - predicted PARP Inhibitor (Pan)
BRCA1 T37Qfs*13 loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q1894* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 A1708E loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 P1771R loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 E2229* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM del loss of function PARP Inhibitor (Pan)
BRCA2 G2585R loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 G3076V loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM E2272* loss of function - predicted PARP Inhibitor (Pan)
BRCA2 N272Kfs*2 loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 E260Sfs*15 loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 K1574fs loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM Q1579fs loss of function - predicted PARP Inhibitor (Pan)
BRCA1 Y1703H loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q480* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 L1407P loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM S719* loss of function - predicted PARP Inhibitor (Pan)
BRCA2 R2645fs loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 W2626C loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 L2686P loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A E654Gfs*9 loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 Y2660D loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 I247Yfs*8 loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 R2318Q loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 V1714G loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q920* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 E2476* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM R1466* loss of function - predicted PARP Inhibitor (Pan)
ARID1A G276Efs*87 loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 D244Rfs*7 loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q403* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 N243Kfs*3 loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 H1746N loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 S1722F loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 R3052W loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 Q2561P loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A E1776* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM E522* loss of function - predicted PARP Inhibitor (Pan)
BRCA1 E577* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM R2034* loss of function - predicted PARP Inhibitor (Pan)
ARID1A Q1212* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM A2067D loss of function PARP Inhibitor (Pan)
BRCA2 Q2925K loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A H203fs loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 E510* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 F2642S loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 T2766Nfs*11 loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 T2515I loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 M1783T loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 M18T loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 E1660G loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 E1114fs loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 G2793E loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 P1856T loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM S978fs loss of function - predicted PARP Inhibitor (Pan)
ATM T2947S loss of function - predicted PARP Inhibitor (Pan)
BRCA1 V340* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 L1844R loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM K468Efs*18 loss of function - predicted PARP Inhibitor (Pan)
BRCA1 L1564P loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 S1841A loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 K2498E loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 E29Sfs*2 loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 W2788R loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q566* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 inact mut loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 V1809A loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 C39S loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q393fs loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 A2603P loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A R727fs loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A M1318fs loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 V1838E loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 E350* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 A1752G loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 T77M loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 L52F unknown PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 R2845fs loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 K339fs loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 D67Y unknown PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 W1718L loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 A1708V loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 K604* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 I1807S loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM dec exp no effect PARP Inhibitor (Pan)
BRCA2 L2653P loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A A344_A348del loss of function EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 C61G unknown PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 Y2997* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A W1545* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 K1487R loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 E49* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM E1978* loss of function - predicted PARP Inhibitor (Pan)
BRCA1 R1443G loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A R750* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 W2725L loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 S196N loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 I1766S loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 Q12Y loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q1519fs loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 I31M loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A L2007del loss of function EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 R1751P loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 D1692H loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 C27A loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q515* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 C24R loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 T3030fs loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 Q1037* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 S1715R loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM R3008H loss of function - predicted PARP Inhibitor (Pan)
BRCA1 S1596Nfs*25 loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 T1685A loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Y551Tfs*68 loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 Y1853C loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 T3033I loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 R1443* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 D1739Y loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 D1739E loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 E1441* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 H1686Q loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 P1749R loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 C39R loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM C353fs loss of function - predicted PARP Inhibitor (Pan)
ARID1A Q1493* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 G2748D loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q1148* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 C44F loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 K2630Q loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 M1652K loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM V1941L loss of function - predicted PARP Inhibitor (Pan)
BRCA2 loss loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM P2699S loss of function - predicted PARP Inhibitor (Pan)
BRCA1 A1752P loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM R2832C loss of function PARP Inhibitor (Pan)
BRCA2 S1982fs loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 L1780P loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A R774Efs*55 loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A S11fs loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 L3125H loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 T1700A loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q1584* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A S674fs loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 E673* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q1342fs loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 E23fs loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 W2788S loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 G1743R loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM C540* loss of function - predicted PARP Inhibitor (Pan)
ATM D1682Y loss of function - predicted PARP Inhibitor (Pan)
ARID1A Q543* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 V211I loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 G1788V loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A V1561fs loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 K654fs loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 G1788D loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM inact mut loss of function PARP Inhibitor (Pan)
BRCA2 Q1782fs loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 F1761I loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM V278fs loss of function - predicted PARP Inhibitor (Pan)
BRCA1 M1775E loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 A1789T loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 M18K loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 S1970* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 Y42C loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 D1692Y loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 P2800R loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 del loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A W1670* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 S1715N loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 F2562L loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 E3002D loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A loss loss of function EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 Q548* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 L2080* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 Q202* loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A E1780* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 I42V unknown PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q546Rfs*73 loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 L392Qfs*5 loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A G319fs loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM loss loss of function PARP Inhibitor (Pan)
ATM H1380Y loss of function - predicted PARP Inhibitor (Pan)
BRCA1 F1761S loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A Q633* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 T582P loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 G3076R loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 R2784Q loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 V1833M loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 I2672fs loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 Q2925R loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 V1833E loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 Q1811R loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 S1841N loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 A1843P loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 R2842L loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA2 N257Kfs*17 loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 W1837G loss of function PARP Inhibitor (Pan) PARP-1 Inhibitor
BRCA1 K38Sfs*12 loss of function - predicted PARP Inhibitor (Pan) PARP-1 Inhibitor
ARID1A S617* loss of function - predicted EZH2 inhibitor PARP Inhibitor (Pan) PARP-1 Inhibitor
ATM R3047* loss of function - predicted PARP Inhibitor (Pan)
ATM R805* loss of function - predicted PARP Inhibitor (Pan)