Drug Class Detail

Drug Class PDPK1 Inhibitor

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Drug Name Trade Name Synonyms Drug Classes Drug Description
BX-320 PDPK1 Inhibitor 10 BX-320 is a small molecule inhibitor of PDPK1, which may block cell growth and induce apoptosis (PMID: 15772071).
PHT-427 Akt Inhibitor (Pan) 17 PDPK1 Inhibitor 10 PHT-427 is an AKT inhibitor, which binds to the PH domain of AKT and has demonstrated antitumor activity in xenograft models (PMID: 19491272, PMID: 20197390).
GSK2334470 PDPK1 Inhibitor 10 GSK2334470 is a small molecule inhibitor of PDPK1, which subsequently results in suppression of Akt and may result in antiproliferative activity (Cancer Res April 15, 2010 70; LB-116).
SA16 Aurka Inhibitors 23 PDPK1 Inhibitor 10 SA16 is a dual inhibitor of phosphoinositide-dependent kinase-1 (PDPK1) and AURKA, which may result in cell proliferation blockade and induction of apoptosis (PMID: 27797168).
OSU03012 AR-12|OSU-03012 PDPK1 Inhibitor 10 OSU03012 is an inhibitor of PDPK1, which can indirectly inhibit beta-catenin by blocking Akt signaling resulting in apoptosis and anti-tumor activity (PMID: 20028853).
BX-795 BX795 PDPK1 Inhibitor 10 BX-795 is a small molecule inhibitor of PDPK1, as well as TBK and IKBKE, which may result in inhibition of cell growth (PMID: 23887393, PMID: 28455392).
SNS-510 PDPK1 Inhibitor 10 SNS-510 binds to and inhibits PDPK1 (PDK1), resulting in reduced downstream signaling, and potentially leading to decreased tumor cell proliferation and tumor growth inhibition (Mol Cancer Ther, Dec 1 2015 (14) (12 Supplement 2) C198).
BX-912 PDPK1 Inhibitor 10 BX-912 is a small molecule inhibitor of PDPK1, which may result in cell growth inhibition and apoptotic activity (PMID: 15772071).
MP7 PDPK1 Inhibitor 10 MP7 is an inhibitor of phophoinostodine-dependent kinase (PDPK1), which, when combined with other agents, may result in inhibition of cell proliferation and reduced viability of cancer cells (PMID: 27797168).
SNS-229 PDPK1 Inhibitor 10 SNS-229 binds to and inhibits PDPK1 (PDK1), resulting in reduced downstream signaling, and potentially leading to decreased tumor cell proliferation and tumor growth inhibition (Mol Cancer Ther, Dec 1 2015 (14) (12 Supplement 2) C198).
Molecular Profile Protein Effect Treatment Approaches
CTNNB1 S45T gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 G34E gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 P44A gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S33A gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S45A gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 W25_D32del gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 E54K gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 D32N gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 H36Y gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 I35S gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 G34R gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 H36P gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S45C gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S37T gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S45N gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 G38P gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S37Y gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 A39T gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 D32Y gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S33P gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S33N gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 I35N gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 G34A gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S37C gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 T41A gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 G34V gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S33C gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 T41I gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 act mut gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S37P gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 D32V gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S37A gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 A43T gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S45F gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 A21T gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 G48D gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S33Y gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 D32H gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 K335I gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 P44_S45del gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 W383R gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S33L gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 D32A gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 A39G gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S45Y gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 E67K gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 D32G gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 V22A gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S33T gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S45del gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 A43P gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S45P gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S37F gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 I35T gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 A13T gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S33F gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 N387K gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 D32E gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor