Drug Class Detail

Drug Class S6 Kinase Inhibitor

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Drug Name Trade Name Synonyms Drug Classes Drug Description
M2698 MSC2363318A Akt Inhibitor (Pan) 17 S6 Kinase Inhibitor 5 M2698 (MSC2363318A) binds to and inhibits the activity of P70S6K and AKT, which prevents the activation of the PI3K/AKT/P70S6K signaling pathway, thereby inhibiting tumor cell proliferation (PMID: 27186432).
LYS6KAKT1 Akt Inhibitor (Pan) 17 AKT Inhibitor (Pan) - ATP competitive 7 S6 Kinase Inhibitor 5 LYS6KAKT1 is an ATP-competitive inhibitor of AKT and p70 S6 kinases, which prevents signaling of the PI3K/AKT pathway and may result in decreased tumor volume and slowed tumor growth (Mol Cancer Ther 2011;10(11 Suppl):Abstract nr B117).
AT-7867 AT7687 Akt Inhibitor (Pan) 17 AKT Inhibitor (Pan) - ATP competitive 7 PKA Inhibitor 2 S6 Kinase Inhibitor 5 AT7867 is an ATP-competitive inhibitor of AKT1, AKT2, AKT3, PKA, and P70S6K, which inhibits cell proliferation and tumor growth (PMID: 20423992).
LY2780301 Akt Inhibitor (Pan) 17 S6 Kinase Inhibitor 5 LY2780301 is an inhibitor of AKT and P70S6 kinases, which prevents signaling of the PI3K/AKT pathway thereby possibly resulting in antitumor activity (PMID: 25902900).
AD80 RET Inhibitor 36 S6 Kinase Inhibitor 5 AD80 inhibits several kinases including RET and S6K, which may result in decreased tumor growth (PMID: 22678283, PMID: 28249155).
Molecular Profile Protein Effect Treatment Approaches