Drug Class Detail

Drug Class VEGFR1 Inhibitor

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Semaxanib SU5416 FLT3 Inhibitor 48 VEGFR1 Inhibitor 4 VEGFR2 Inhibitor 34 Semaxanib (SU5416) is an inhibitor of FLT1 (VEGFR1), KDR (VEGFR2), and FLT3, which inhibits tumor vascularization and growth (PMID: 9892193, PMID: 12351406).
Brivanib BMS-540215 FGFR1 Inhibitor 21 VEGFR1 Inhibitor 4 VEGFR2 Inhibitor 34 Brivanib (BMS-540215) selectively binds and inhibits KDR (VEGFR2), while demonstrating moderate activity against VEGFR1 and FGFR1, which inhibits tumor angiogenesis, tumor cell growth, and induces tumor regression (PMID: 18829493, PMID: 16570908).
MK2461 MET Inhibitor 50 PDGFR Inhibitor (Pan) 27 RON Inhibitor 10 VEGFR1 Inhibitor 4 MK2461 inhibits wild-type and activated forms of MET, and also has activity against VEGFR1 (FLT1), MST1R (RON), and PDGFR resulting in inhibition of downstream signaling and decreased tumor growth (PMID: 20145145).
Cediranib AZD-2171|Recentin KIT Inhibitor 48 VEGFR1 Inhibitor 4 VEGFR2 Inhibitor 34 VEGFR3 Inhibitor 5 Cediranib (AZD-2171) is an ATP-competitive inhibitor of all three vascular endothelial growth factor receptors (FLT1, KDR, and FLT4) and KIT, thereby blocking VEGF-signaling, angiogenesis, and tumor cell growth (PMID: 15899831, PMID: 24714778).
Molecular Profile Protein Effect Treatment Approaches