Drug Class Detail

Drug Class WNT Inhibitor

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Drug Name Trade Name Synonyms Drug Classes Drug Description
LGK974 WNT974 WNT Inhibitor 9 LGK974 binds to and inhibits porcupine (PORCN), resulting in decreased secretion of Wnt ligands and concomitant decrease in Wnt signaling, potentially resulting in reduced cell growth in tumors with dysregulated Wnt signaling (NCI Drug Dictionary).
ETC-159 ETC-1922159 WNT Inhibitor 9 ETC-159 is a small molecule inhibitor of PORCN, which is demonstrated to suppress Wnt signaling and may result in inhibition of cell growth and lead to upregulation of genes related to cell differentiation (PMID: 26257057).
GSK3178022 WNT Inhibitor 9 GSK3178022 is an antibody that targets LRP6 and blocks both Wnt binding domains, resulting in decreased Wnt-mediated signaling and potentially leading to decreased tumor growth (PMID: 27401612).
SJ26 WNT Inhibitor 9 SJ26 binds the G-quadruplex structure of the WNT1 promoter to inhibit Wnt1 expression and signaling, thereby preventing cell migration (PMID: 27626678).
SM08502 WNT Inhibitor 9 SM08502 is a small molecule inhibitor of Wnt signaling that may regulate cell proliferation (NCI Drug Dictionary).
WNT-C59 WNT Inhibitor 9 WNT-C59 is a small molecule inhibitor of PORCN, which subsequently inhibits Wnt/beta-catenin signaling and thus, may result in tumor growth reduction (PMID: 25980501).
Vantictumab anti-Fzd7|OMP-18R5 WNT Inhibitor 9 Vantictumab (OMP-18R5) is a monoclonal antibody that targets Frizzled receptors 1, 2, 5, 7, and 8, resulting in decreased Wnt signaling and potentially leading to decreased tumor growth (PMID: 22753465).
Rosmantuzumab OMP-131R10 WNT Inhibitor 9 Rosmantuzumab (OMP-131R10) is a monoclonal antibody that targets R-spondin 3 (RSPO3), which results in decreased pathway activation and may lead to reduced tumor cell proliferation and decreased survival of cancer stem cells (NCI Drug Dictionary).
Ipafricept Fzd8-Fc|OMP-54F28 WNT Inhibitor 9 Ipafricept (OMP-54F28) is a fusion protein comprised of the ligand binding domain of the Frizzled family receptor 8 and the human immunoglobulin Fc domain, which binds Wnt and prevents downstream signaling, thereby inhibiting tumor growth (PMID: 25172549).
Molecular Profile Protein Effect Treatment Approaches