Drug Class Detail

Drug Class mTOR Inhibitor

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Drug Name Trade Name Synonyms Drug Classes Drug Description
WYE-687 mTOR Inhibitor 48 WYE-687 inhibits mTOR signaling through mTORC1 and mTORC2, thereby promoting cell cycle arrest and apoptosis (PMID: 19584280).
GDC-0980 Apitolisib mTOR Inhibitor 48 PI3K Inhibitor (Pan) 34 Apitolisib (GDC-0980) is an inhibitor of both PI3K and mTOR kinases, resulting in decreased phosphorylation of PI3K/Akt/mTOR pathway markers, which may lead to inhibition of tumor growth and tumor regression (PMID: 21998291).
SAR245409 XL765|Voxtalisib mTOR Inhibitor 48 PI3K Inhibitor (Pan) 34 XL765 (SAR245409) inhibits both PI3K and mTOR kinases and results in inhibition of PI3K pathway signaling, thereby possibly leading to inhibition of cell proliferation, reduced tumor vascularization, and inhibition of tumor growth (PMID: 24634413).
ABTL0812 mTOR Inhibitor 48 ABTL0812 is a lipid analog that inhibits mTOR and DHFR, potentially resulting in decreased tumor cell proliferation and increased tumor cell death (Cancer Res April 15, 2012 72:922).
PKI-402 mTOR Inhibitor 48 PI3K Inhibitor (Pan) 34 PKI-402 is a dual ATP-competitive mTOR/PI3K inhibitor, which leads to reduced downstream signaling, potentially resulting in decreased tumor growth (PMID: 20371716).
RapaLink-1 mTOR Inhibitor 48 RapaLink-1 is a hybrid inhibitor of both mTORC1 and mTORC2 that binds to ATP and FRB sites, and may result in inhibition of mTOR signaling and decreased tumor growth (PMID: 27279227).
BEZ235 NVP-BEZ235|Dactolisib ATR Inhibitor 9 mTOR Inhibitor 48 PI3K Inhibitor (Pan) 34 BEZ235 inhibits PI3K kinase, mTOR kinase, and ATR, which may result in tumor cell apoptosis and growth inhibition of tumor cells (PMID: 18606717, PMID: 21552262).
VS-5584 SB-23430 mTOR Inhibitor 48 PI3K Inhibitor (Pan) 34 VS-5584 inhibits mTOR kinase and all class I PI3K isoforms, disrupting phosphorylation of substrates downstream of PI3K and mTOR, thereby preventing cell proliferation and inhibiting tumor growth (PMID: 23270925).
DHM25 mTOR Inhibitor 48 DHM25 is an mTOR inhibitor that inhibits the activity of mTORC1 and mTORC2, potentially resulting in decreased tumor growth (PMID: 26237138).
BGT226 mTOR Inhibitor 48 PI3K Inhibitor (Pan) 34 BGT226 is a dual inhibitor of class I PI3K kinases and mTOR, which inhibits cell proliferation (PMID: 21976531).
CC-115 mTOR Inhibitor 48 CC-115 binds to and inhibits the activity of DNA-PK and mTOR, which may lead to reduced cell proliferation, block downstream signaling, and induce cell death (PMID: 27235137).
PF-04691502 mTOR Inhibitor 48 PI3K Inhibitor (Pan) 34 PF-04691502 is a PI3K/mTOR dual inhibitor with broad antitumor activity (PMID: 21750219).
Torin 1 mTOR Inhibitor 48 Torin 1 inhibits mTOR signaling through mTORC1 and mTORC2, thereby preventing cell proliferation (PMID: 19209957).
Vistusertib AZD2014 mTOR Inhibitor 48 Vistusertib (AZD2014) inhibits the activity of mTOR, which may result in tumor growth inhibition (PMID: 23375793).
OSI-027 mTOR Inhibitor 48 OSI-027 is an ATP-competitive inhibitor of mTOR that blocks mTORC1/2 signaling, which leads to inhibition of cell proliferation (PMID: 21363918).
CC214-2 mTOR Inhibitor 48 CC214-2 is an ATP-competitive mTOR inhibitor, which inhibits signaling through mTORC1 and mTORC2, potentially resulting in decreased tumor cell growth (PMID: 24030701, PMID: 23414803).
CC-223 mTOR Inhibitor 48 CC-223 is a selective inhibitor of mTOR that induces apoptosis and growth inhibition in tumor cells (PMID: 25855786).
Gedatolisib PKI-587|PF-05212384 mTOR Inhibitor 48 PI3K Inhibitor (Pan) 34 Gedatolisib (PF-05212384) is an ATP-competitive inhibitor that targets phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway, and may result in antitumor activity, including inhibition of tumor growth and tumor regression (PMID: 21325073).
Torin 2 ATM Inhibitor 6 ATR Inhibitor 9 mTOR Inhibitor 48 Torin 2 inhibits ATM, ATR and mTOR signaling through mTORC1/2, thereby preventing cell proliferation (PMID: 21322566, PMID: 23436801).
DS-7423 DS7423 mTOR Inhibitor 48 PI3K Inhibitor (Pan) 34 DS-7423 inhibits both PI3K kinase and mTORC1/2, which may result in tumor cell apoptosis and suppression of tumor growth (PMID: 24504419).
GDC-0084 mTOR Inhibitor 48 PI3K Inhibitor (Pan) 34 GDC-0084 is a dual pan-PI3K and mTOR inhibitor, which prevents cell proliferation and potentially inhibits tumor growth (PMID: 22619466).
PP30 mTOR Inhibitor 48 PP30 inhibits mTOR signaling through mTORC1 and mTORC2, thereby preventing cell proliferation (PMID: 19209957).
Itraconazole Hyphanox ITC mTOR Inhibitor 48 Itraconazole is an antifungal, which indirectly targets mTOR (PMID: 20176935).
KU-0063794 mTOR Inhibitor 48 KU-0063794 is an mTOR inhibitor with activity against both mTORC1 and mTORC2, which prevents cell proliferation (PMID: 19402821).
XL388 mTOR Inhibitor 48 XL388 is a selective ATP-competitive mTOR inhibitor that inhibits mTORC1 and mTORC2, resulting in decreased activation of downstream targets and potentially leading to decreased tumor growth (PMID: 23394126).
Panulisib P7170 ALK Inhibitor 19 DNA_PK Inhibitor 5 mTOR Inhibitor 48 PI3K Inhibitor (Pan) 34 Panulisib (P7170) inhibits Pi3k, mTOR, Alk, and DNA-PK, resulting in inhibition of cancer cell growth (PMID: 25466244).
WYE-354 mTOR Inhibitor 48 WYE-354 inhibits mTOR signaling through mTORC1 and mTORC2, thereby promoting cell cycle arrest and apoptosis (PMID: 19584280).
Sapanisertib INK128|sapanisertib|TAK-228|MLN0128 mTOR Inhibitor 48 Sapanisertib (MLN0128) is an ATP-competitive mTOR kinase inhibitor that induces apoptosis and inhibits growth in tumor cells (PMID: 25519700).
PWT33597 mTOR Inhibitor 48 PIK3CA inhibitor 14 PWT33597 is a dual PIK3CA and mTOR inhibitor, which may induce apoptosis in cells with activated PI3K or mTOR pathways (Cancer Res 2011;71(8 Suppl):Abstract nr 4485).
GNE-317 mTOR Inhibitor 48 PI3K Inhibitor (Pan) 34 GNE-317 is a dual PI3K/mTOR inhibitor that crosses the blood-brain barrier, resulting in decreased downstream signaling and potentially leading to reduced growth of tumors, including brain tumors (PMID: 22992516).
PP-121 ABL Inhibitor (pan) 8 mTOR Inhibitor 48 PDGFR Inhibitor (Pan) 27 SRC Inhibitor 26 VEGFR2 Inhibitor 34 PP-121 inhibits several types of kinases including, PDGFR, Hck, mTOR, KDR (VEGFR2), Src and Abl to prevent cell proliferation (PMID: 24867098).
GSK2126458 GSK458|Omipalisib mTOR Inhibitor 48 PI3K Inhibitor (Pan) 34 GSK2126458 is a dual pan-PI3K and mTOR inhibitor, which blocks PI3K/AKT signaling to prevent cell proliferation (PMID: 24900173).
X480 mTOR Inhibitor 48 PI3K Inhibitor (Pan) 34 X480 is a dual PI3K/mTOR inhibitor, which may lead to decreased tumor growth and metastasis (Eur J Cancer, 2012, 48, S5:235).
WAY-600 mTOR Inhibitor 48 WAY-600 inhibits mTOR signaling through mTORC1 and mTORC2, thereby promoting cell cycle arrest and apoptosis (PMID: 19584280).
Torkinib PP242 mTOR Inhibitor 48 Torkinib (PP242) inhibits mTOR signaling through mTORC1/2, thereby preventing cell proliferation (PMID: 19209957).
CC214-1 mTOR Inhibitor 48 CC214-1 is an ATP-competitive mTOR inhibitor, which inhibits signaling through mTORC1 and mTORC2, potentially resulting in decreased tumor cell growth (PMID: 24030701).
PKI-179 mTOR Inhibitor 48 PI3K Inhibitor (Pan) 34 PKI-179 is a dual PI3K/mTORC1/2 inhibitor that inhibits the PI3K/mTOR signaling pathway, thereby inducing apoptosis and inhibiting tumor growth (PMID: 20797855).
GDC-0349 mTOR Inhibitor 48 GDC-0349 is a selective ATP-competitive inhibitor of mTOR kinase activity, which may lead to growth inhibition of tumor cells (PMID: 23473235, PMID: 26759240).
GSK1059615 mTOR Inhibitor 48 PI3K Inhibitor (Pan) 34 GSK1059615 is a dual pan-PI3K/mTOR inhibitor, which prevents cell proliferation (PMID: 24900173).
DS-3078a mTOR Inhibitor 48 DS-3078a is a small molecule that inhibits mTOR kinase activity and downstream signaling, resulting in decreased tumor cell growth (Mol Cancer Ther 2013;12(11 Suppl):B184).
DCBCI0901 mTOR Inhibitor 48 PI3K Inhibitor (Pan) 34 DCBCI0901 is an inhibitor of PI3K, mTORC1, and mTORC2, which may result in antitumor activity, including inhibition of cell survival, proliferation, and tumor growth (Mol Cancer Ther 2013;12(11 Suppl):Abstract nr C270).
LY3023414 mTOR Inhibitor 48 PI3K Inhibitor (Pan) 34 LY3023414 is an ATP competitive inhibitor of PI3K/mTOR, inhibits signaling of the PI3K/mTOR pathway, and has demonstrated antiproliferative activity against tumor cells (PMID: 24387334).
PQR309 PQR 309|bimiralisib mTOR Inhibitor 48 PI3K Inhibitor (Pan) 34 PQR309 (bimiralisib) is a dual pan-PI3K and mTORC1/2 inhibitor, which blocks PI3K/mTOR signaling, potentially resulting in inhibition of tumor growth (PMID: 29066507).
AZD8055 mTOR Inhibitor 48 PI3K Inhibitor (Pan) 34 AZD8055 is a PI3K/MTOR inhibitor that reduces downstream signaling, resulting in decreased tumor cell growth (PMID: 20028854)
WYE-125132 WYE-132 mTOR Inhibitor 48 WYE-125132 (WYE-132) inhibits mTOR signaling through mTORC1/2, thereby preventing cell proliferation (PMID: 20068177).
Antroquinonol Hocena Hocena mTOR Inhibitor 48 Hocena (antroquinonol) is derived from the fungus, Antrodia camphorata, and has been reported to have antitumor effects against various cancer cells through inhibition of mTOR (PMID: 21185843).
AR-mTOR-26 AR mTOR 26 mTOR Inhibitor 48 AR-mTOR-26 is a selective inhibitor of mTOR, which leads to decreased signaling through mTORC1 and mTORC2, and may lead to decreased tumor growth (Cancer Res April 15, 2010 70; 4484).
RES-529 Palomid 529|P529 mTOR Inhibitor 48 RES-529 (Palomid 529) inhibits mTOR signaling though mTORC1 and mTORC2, which prevents cell proliferation (PMID: 19010932).
Molecular Profile Protein Effect Treatment Approaches
STK11 E199K loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 D277Y loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 L245R loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Q170* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 P281L loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E57fs loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Q159* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 K44* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 F157S loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Q220* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 loss loss of function mTOR Inhibitor mTORC1 Inhibitor
STK11 E121* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 D53Tfs*11 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E223V loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E165* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Q137* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 D194E loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 W308C loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 K62* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 D194Y loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 inact mut loss of function mTOR Inhibitor mTORC1 Inhibitor
STK11 N181E loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 T250P loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 A205T loss of function mTOR Inhibitor mTORC1 Inhibitor
STK11 E138* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Q123* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 A218Sfs*42 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Q100* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E199* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 P281fs loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 G61Afs*3 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 I35Lfs*127 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 L285Lfs*2 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E57Sfs*107 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 K84* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Y60* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 L282Afs*3 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 H174R loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 K78A loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 G56Tfs*4 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Q170P loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 L285Q loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 K62Sfs*100 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Q214* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Q37* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 G171S loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Y272H loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 K78I loss of function mTOR Inhibitor mTORC1 Inhibitor
STK11 P281Rfs*6 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 S216F loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 P281Pfs*4 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 G163D loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 D176Y loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E70* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E65* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 M136R loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E223* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E120* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 F354L loss of function mTOR Inhibitor mTORC1 Inhibitor
STK11 K48fs loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Y118* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 D207Gfs*59 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 I177N loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E33* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 R304W loss of function mTOR Inhibitor mTORC1 Inhibitor
STK11 L67P loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 D176N loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor