Drug Class Detail

Drug Class mTORC1 Inhibitor

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Zotarolimus ABT-578 mTORC1 Inhibitor 8 Zotarolimus (ABT-578) is a rapamycin analogue, which inhibits FKBP-12 to prevent mTOR signaling (PMID: 19075588).
Temsirolimus Torisel CCI-779 mTORC1 Inhibitor 8 Torisel (temsirolimus) binds to FKBP-12 and allosterically inhibits mTOR (PMID: 16883305). Torisel (temsirolimus) is FDA approved for advanced renal cell carcinoma (FDA.gov).
Nab-Rapamycin ABI-009 mTORC1 Inhibitor 8 Nab-Rapamycin is nanoparticle albumin-bound rapamycin that has immunosuppressant and anti-tumor activities (PMID: 24089446).
Everolimus Afinitor RAD001|Zortress mTORC1 Inhibitor 8 Afinitor (everolimus) binds to FKBP-12 and allosterically inhibits mTOR, leading to decreased mTORC1 signaling and potentially resulting in decreased tumor cell growth (PMID: 17766661, PMID: 28400999). Afinitor (everolimus) is FDA approved for use in neuroendocrine tumors of pancreatic, lung or gastrointestinal tract origin, advanced renal cell carcinoma, and in combination with Aromasin (exemestane) in hormone receptor-positive, HER2-negative breast cancer (FDA.gov).
Ridaforolimus AP23573|MK-8669|Deforolimus mTORC1 Inhibitor 8 Ridaforolimus (MK-8669) is a rapamycin analogue, which allosterically inhibits mTOR to inhibit cell proliferation (PMID: 21482695).
Sirolimus Rapamune Rapamycin mTORC1 Inhibitor 8 Rapamune (sirolimus) binds to the FKBP-12 to generate an immunosuppressive complex that binds and allosterically inhibits mTOR (NCI Drug Dictionary, PMID: 25261369). Rapamune (sirolimus) is FDA approved for the prevention of renal transplant rejection and for patients with lymphangioleiomyomatosis (FDA.gov).
PI-103 mTORC1 Inhibitor 8 PI3K Inhibitor (Pan) 34 PI-103 is a dual pan-PI3K/mTOR inhibitor, which blocks PI3K/AKT/mTOR signaling and potentially inhibits cell proliferation (PMID: 16697955).
Triolimus Antimicrotubule Agent 11 HSP90 Inhibitor 35 mTORC1 Inhibitor 8 Triolimus is a composed of a micelle containing the drugs rapamycin, 17-AAG, and paclitaxel, which act synergistically to inhibit tumor growth (PMID: 22896668).
Molecular Profile Protein Effect Treatment Approaches
VHL N78S loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
STK11 Y272H loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 D176Y loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
FBXW7 E369* loss of function - predicted mTORC1 Inhibitor
STK11 K78I loss of function mTOR Inhibitor mTORC1 Inhibitor
STK11 P281Rfs*6 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
FBXW7 R505L loss of function mTORC1 Inhibitor
VHL L116fs loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
VHL W117C loss of function mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
FBXW7 W244* loss of function - predicted mTORC1 Inhibitor
STK11 S216F loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
FBXW7 R465P loss of function - predicted mTORC1 Inhibitor
STK11 Q100* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E57fs loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 K62* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
FBXW7 K11R loss of function - predicted mTORC1 Inhibitor
STK11 E121* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E120* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
VHL V130F loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
STK11 H174R loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
VHL D126N loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
STK11 M136R loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
FBXW7 R479* loss of function - predicted mTORC1 Inhibitor
VHL S111R loss of function mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
VHL L184P loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
STK11 D207Gfs*59 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
VHL R82P loss of function mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
STK11 P281fs loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
FBXW7 R367* loss of function - predicted mTORC1 Inhibitor
VHL S65W loss of function mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
FBXW7 Q275* loss of function - predicted mTORC1 Inhibitor
FBXW7 R479Q loss of function mTORC1 Inhibitor
STK11 E57Sfs*107 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E138* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
FBXW7 inact mut loss of function mTORC1 Inhibitor
STK11 W308C loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 I35Lfs*127 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
VHL F148fs loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
VHL S68* loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
FBXW7 R465L loss of function mTORC1 Inhibitor
STK11 P281L loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
VHL C77* loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
FBXW7 R473fs loss of function - predicted mTORC1 Inhibitor
VHL N131fs loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
VHL inact mut loss of function mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
STK11 D176N loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 L67P loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
VHL R79P loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
STK11 P281Pfs*4 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 K48fs loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 A205T loss of function mTOR Inhibitor mTORC1 Inhibitor
STK11 A218Sfs*42 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E223* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Q220* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E199* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
VHL P81S loss of function mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
VHL H110Q unknown mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
VHL Q96* loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
STK11 D194Y loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
FBXW7 G423* loss of function - predicted mTORC1 Inhibitor
FBXW7 H420Y loss of function - predicted mTORC1 Inhibitor
STK11 I177N loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 F354L loss of function mTOR Inhibitor mTORC1 Inhibitor
VHL W88* loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
STK11 T250P loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
FBXW7 G499Vfs*25 loss of function - predicted mTORC1 Inhibitor
FBXW7 S227A loss of function - predicted mTORC1 Inhibitor
FBXW7 R278* loss of function - predicted mTORC1 Inhibitor
VHL V74G loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
VHL S80I loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
FBXW7 R479P loss of function - predicted mTORC1 Inhibitor
STK11 F157S loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 N181E loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 G56Tfs*4 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
FBXW7 T165fs loss of function - predicted mTORC1 Inhibitor
FBXW7 W237* loss of function - predicted mTORC1 Inhibitor
VHL V155fs loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
STK11 inact mut loss of function mTOR Inhibitor mTORC1 Inhibitor
STK11 K78A loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 K62Sfs*100 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
FBXW7 K444fs loss of function - predicted mTORC1 Inhibitor
FBXW7 R479H loss of function mTORC1 Inhibitor
STK11 Q214* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
FBXW7 R465C loss of function mTORC1 Inhibitor
STK11 G171S loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Q170* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
VHL R167W loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
STK11 Q123* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
VHL S68fs loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
VHL C162F loss of function mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
STK11 E65* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 loss loss of function mTOR Inhibitor mTORC1 Inhibitor
STK11 Q170P loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
FBXW7 R393* loss of function - predicted mTORC1 Inhibitor
STK11 E199K loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
VHL Y98H loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
FBXW7 W486* loss of function - predicted mTORC1 Inhibitor
VHL R167Q loss of function mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
FBXW7 R479L loss of function mTORC1 Inhibitor
STK11 Q159* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
VHL P86H loss of function mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
VHL Y112H loss of function mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
FBXW7 I435fs loss of function - predicted mTORC1 Inhibitor
VHL H115R loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
FBXW7 S282* loss of function - predicted mTORC1 Inhibitor
STK11 L245R loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
VHL P154L loss of function mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
VHL S111N loss of function mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
STK11 D277Y loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
FBXW7 K299fs loss of function - predicted mTORC1 Inhibitor
STK11 E165* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
VHL H115Q loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
STK11 L282Afs*3 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E70* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 G61Afs*3 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
VHL V62fs loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
STK11 L285Q loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
FBXW7 T15_G16insP loss of function mTORC1 Inhibitor
STK11 D53Tfs*11 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
VHL S80R loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
VHL L158P loss of function mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
VHL loss loss of function mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
FBXW7 del loss of function mTORC1 Inhibitor
STK11 K84* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
FBXW7 R465H loss of function mTORC1 Inhibitor
FBXW7 R505C loss of function mTORC1 Inhibitor
FBXW7 Q47* loss of function - predicted mTORC1 Inhibitor
STK11 Q137* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 Q37* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
FBXW7 loss loss of function mTORC1 Inhibitor
VHL G114R loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
VHL C162W loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
STK11 Y118* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
VHL L158fs loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
VHL S65L loss of function mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
VHL Q132fs loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
STK11 E33* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
VHL R161P loss of function mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
VHL N90I loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
FBXW7 R222* loss of function - predicted mTORC1 Inhibitor
STK11 G163D loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 L285Lfs*2 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 E223V loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 K44* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 D194E loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
VHL R161G loss of function - predicted mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
STK11 Y60* loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
STK11 R304W loss of function mTOR Inhibitor mTORC1 Inhibitor
FBXW7 H460R loss of function - predicted mTORC1 Inhibitor
FBXW7 R465Y loss of function - predicted mTORC1 Inhibitor
VHL S183L loss of function mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor
FBXW7 R224* loss of function - predicted mTORC1 Inhibitor
FBXW7 R479G loss of function - predicted mTORC1 Inhibitor
VHL Y98N loss of function mTORC1 Inhibitor VEGFR Inhibitor (Pan) VEGFR2 Inhibitor