Drug Class Detail

Drug Class p53 Activator

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Drug Name Trade Name Synonyms Drug Classes Drug Description
NSC319726 p53 Activator 9 NSC319726 restores wild-type conformation to mutant Tp53, resulting in reactivation of Tp53 signaling in Tp53-mutant cells, and potentially leading to increased tumor cell death (PMID: 22624712).
thioureidobutyronitrile Kevetrin p53 Activator 9 Kevetrin (thioureidobutyronitrile) leads to stabilization of wild-type p53 and degradation of mutant p53, resulting in apoptosis and decreased growth of tumors with wild-type and mutant p53 (J Clin Oncol 31, 2013 (suppl; abstr TPS2627)).
Serdemetan JNJ-26854165 p53 Activator 9 Serdemetan (JNJ-26854165) is a small molecule that regulates ABCA1 expression and inhibits cholesterol transport, resulting in activation of p53 and increased cell death in p53 wild-type and mutant cells (PMID: 23820125).
APR-246 p53 activator APR-246|PRIMA-1MET|PRIMA-1 analogue APR-246 p53 Activator 9 APR-246 is an analogue of PRIMA-1, which modifies the core domain of mutant p53, resulting in restoration of wild-type p53 conformation and reactivation of normal p53 function, leading to increased cell cycle arrest and tumor cell death (PMID: 20498645).
CP-31398 p53 Activator 9 CP-31398 stabilizes wild-type Tp53 conformation, and activates Tp53 activity in cells with wild-type or mutant Tp53, potentially resulting in increased tumor cell death (PMID: 14614447).
COTI-2 p53 Activator 9 COTI-2 is a small molecule that targets mutant Tp53 and potentially inhibits tumor cell growth, alone or in combination with other agents (PMID: 28756138, PMID: 27150056, PMID: 29364966).
ReACp53 p53 Activator 9 ReACp53 is a peptide that inhibits Tp53 aggregation, resulting in reactivation of Tp53 pathway signaling in Tp53-mutant cells, and potentially resulting in increased tumor cell death (PMID: 26748848)
NSC59984 p53 Activator 9 NSC59984 is a small molecule that both induces degradation of mutant Tp53 and reactivates Tp53 pathway signaling through Tp73, which may result in increased cell death in Tp53-mutant tumor cells (PMID: 26294215).
Prodigiosin p53 Activator 9 Prodigiosin is a small molecule that restores Tp53 function through activation of Tp73, resulting in tumor suppression (PMID: 24247721).
Molecular Profile Protein Effect Treatment Approaches
TP53 R280I unknown p53 Activator p53 Gene Therapy
TP53 Y236C loss of function p53 Activator p53 Gene Therapy
TP53 C242Y loss of function - predicted p53 Activator p53 Gene Therapy
TP53 R337P loss of function p53 Activator p53 Gene Therapy
TP53 V274F loss of function p53 Activator p53 Gene Therapy
TP53 P151S loss of function p53 Activator p53 Gene Therapy
TP53 R248E unknown p53 Activator p53 Gene Therapy
TP53 R158H loss of function p53 Activator p53 Gene Therapy
TP53 R175L loss of function p53 Activator p53 Gene Therapy
TP53 P278S loss of function p53 Activator p53 Gene Therapy
TP53 R249S loss of function p53 Activator p53 Gene Therapy
TP53 G245D loss of function p53 Activator p53 Gene Therapy
TP53 R196G loss of function - predicted p53 Activator p53 Gene Therapy
TP53 R280A loss of function p53 Activator p53 Gene Therapy
TP53 R249T unknown p53 Activator p53 Gene Therapy
TP53 P151H loss of function p53 Activator p53 Gene Therapy
TP53 E180K loss of function p53 Activator p53 Gene Therapy
TP53 D7A loss of function - predicted p53 Activator p53 Gene Therapy
TP53 H179L loss of function - predicted p53 Activator p53 Gene Therapy
TP53 N235D loss of function p53 Activator p53 Gene Therapy
TP53 V173A loss of function - predicted p53 Activator p53 Gene Therapy
TP53 G245A loss of function p53 Activator p53 Gene Therapy
TP53 H179Y loss of function p53 Activator p53 Gene Therapy
TP53 R248L loss of function p53 Activator p53 Gene Therapy
TP53 A138T loss of function - predicted p53 Activator p53 Gene Therapy
TP53 Y220C loss of function - predicted p53 Activator p53 Gene Therapy
TP53 I254T loss of function p53 Activator p53 Gene Therapy
TP53 R282del loss of function - predicted p53 Activator p53 Gene Therapy
TP53 P219S loss of function p53 Activator p53 Gene Therapy
TP53 R249K unknown p53 Activator p53 Gene Therapy
TP53 L194F loss of function p53 Activator p53 Gene Therapy
TP53 R248P loss of function - predicted p53 Activator p53 Gene Therapy
TP53 R181P loss of function - predicted p53 Activator p53 Gene Therapy
TP53 R249M loss of function p53 Activator p53 Gene Therapy
TP53 C135S loss of function - predicted p53 Activator p53 Gene Therapy
TP53 R249W gain of function p53 Activator p53 Gene Therapy
TP53 S240I unknown p53 Activator p53 Gene Therapy
TP53 R280D loss of function p53 Activator p53 Gene Therapy
TP53 Y234H loss of function p53 Activator p53 Gene Therapy
TP53 P98A loss of function p53 Activator p53 Gene Therapy
TP53 H179Q loss of function p53 Activator p53 Gene Therapy
TP53 Y163C loss of function p53 Activator p53 Gene Therapy
TP53 S215I loss of function - predicted p53 Activator p53 Gene Therapy
TP53 R273H loss of function p53 Activator p53 Gene Therapy
TP53 E287A loss of function - predicted p53 Activator p53 Gene Therapy
TP53 Y205C loss of function p53 Activator p53 Gene Therapy
TP53 G266R loss of function - predicted p53 Activator p53 Gene Therapy
TP53 S241F loss of function p53 Activator p53 Gene Therapy
TP53 R280T loss of function p53 Activator p53 Gene Therapy
TP53 V272M loss of function - predicted p53 Activator p53 Gene Therapy
TP53 R337L loss of function p53 Activator p53 Gene Therapy
TP53 C141Y loss of function p53 Activator p53 Gene Therapy
TP53 R273W loss of function - predicted p53 Activator p53 Gene Therapy
TP53 R273L loss of function p53 Activator p53 Gene Therapy
TP53 V143A loss of function p53 Activator p53 Gene Therapy
TP53 G245S loss of function p53 Activator p53 Gene Therapy
TP53 F134L loss of function - predicted p53 Activator p53 Gene Therapy
TP53 C277F loss of function p53 Activator p53 Gene Therapy
TP53 inact mut loss of function p53 Activator p53 Gene Therapy
TP53 G245V loss of function p53 Activator p53 Gene Therapy
TP53 L194R loss of function p53 Activator p53 Gene Therapy
TP53 R248G loss of function - predicted p53 Activator p53 Gene Therapy
TP53 H179N loss of function p53 Activator p53 Gene Therapy
TP53 E285V loss of function p53 Activator p53 Gene Therapy
TP53 A159V loss of function p53 Activator p53 Gene Therapy
TP53 G245C loss of function p53 Activator p53 Gene Therapy
TP53 R248W loss of function p53 Activator p53 Gene Therapy
TP53 I251S unknown p53 Activator p53 Gene Therapy
TP53 R158L loss of function - predicted p53 Activator p53 Gene Therapy
TP53 Y327L unknown p53 Activator p53 Gene Therapy
TP53 G244S loss of function p53 Activator p53 Gene Therapy
TP53 R110P loss of function p53 Activator p53 Gene Therapy
TP53 C176F loss of function - predicted p53 Activator p53 Gene Therapy
TP53 M246R loss of function - predicted p53 Activator p53 Gene Therapy
TP53 D281E loss of function - predicted p53 Activator p53 Gene Therapy
TP53 R335H unknown p53 Activator p53 Gene Therapy
TP53 R337C loss of function p53 Activator p53 Gene Therapy
TP53 S241Y loss of function p53 Activator p53 Gene Therapy
TP53 E286K loss of function - predicted p53 Activator p53 Gene Therapy
TP53 G245R unknown p53 Activator p53 Gene Therapy
TP53 R282W loss of function p53 Activator p53 Gene Therapy
TP53 P190S loss of function p53 Activator p53 Gene Therapy
TP53 R273P loss of function p53 Activator p53 Gene Therapy
TP53 P152L loss of function p53 Activator p53 Gene Therapy
TP53 R273C loss of function p53 Activator p53 Gene Therapy
TP53 H168R loss of function p53 Activator p53 Gene Therapy
TP53 S215G loss of function p53 Activator p53 Gene Therapy
TP53 R282Q gain of function p53 Activator p53 Gene Therapy
TP53 V173M loss of function - predicted p53 Activator p53 Gene Therapy
TP53 R273S loss of function p53 Activator p53 Gene Therapy
TP53 Y234C loss of function p53 Activator p53 Gene Therapy
TP53 R175A loss of function - predicted p53 Activator p53 Gene Therapy
TP53 C135F loss of function - predicted p53 Activator p53 Gene Therapy
TP53 R175H loss of function p53 Activator p53 Gene Therapy
TP53 R248Q loss of function p53 Activator p53 Gene Therapy
TP53 R249G loss of function p53 Activator p53 Gene Therapy
TP53 R282D loss of function p53 Activator p53 Gene Therapy
TP53 H193P loss of function p53 Activator p53 Gene Therapy
TP53 M246I loss of function p53 Activator p53 Gene Therapy