Gene Detail
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| Gene Symbol | CDK4 | ||||||||||
| Synonyms | CMM3 | PSK-J3 | ||||||||||
| Gene Description | CDK4, cyclin dependent kinase 4, is a critical regulator of the G1-S cell-cycle transition, inhibits cell senescence and apoptosis (PMID: 24089445) and is also a tumor antigen recognized by T-cells in melanoma (PMID: 29403496). CDK4 dysregulation promotes tumorgenesis in a variety of cancer types (PMID: 24795392) and amplification is common in liposarcoma (PMID: 23569312) and uterine sarcoma (PMID: 32156473). | ||||||||||
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