Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : email@example.com
|Synonyms||CMM3 | PSK-J3|
|Gene Description||CDK4, cyclin dependent kinase 4, is a critical regulator of the G1-S cell-cycle transition, inhibits cell senescence and apoptosis (PMID: 24089445) and is also a tumor antigen recognized by T-cells in melanoma (PMID: 29403496). CDK4 dysregulation promotes tumorgenesis in a variety of cancer types (PMID: 24795392) and amplification is common in liposarcoma (PMID: 23569315) and uterine sarcoma (PMID: 32156473).|