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|Synonyms||CDK4I | INK4B | MTS2 | P15 | p15INK4b | TP15|
|Gene Description||CDKN2B, cyclin dependent kinase inhibitor 2B, regulates G1-S phase cell cycle arrest via specific inhibition of CDK4 and CDK6 kinases to function as a tumor suppressor (PMID: 27030077). CDKN2B deletion and/or promoter hypermethylation is commonly observed in acute lymphoblastic leukemia (PMID: 30635552, PMID: 30592434) and CDKN2B deletions have also been reported in liposarcoma (PMID: 21910158), renal cell carcinoma (PMID: 23898052), and glioma (PMID: 30558563).|