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|Synonyms||CVID13 | Hs.54452 | IK1 | IKAROS | LyF-1 | LYF1 | PPP1R92 | PRO0758 | ZNFN1A1|
|Gene Description||IKZF1, IKAROS family zinc finger 1, is a zinc finger transcription factor that regulates hematopoietic differentiation and immune system development, and functions as a tumor suppressor (PMID: 24659638, PMID: 22150303). Mutations in IKZF1 are associated with acute lymphoblastic leukemia (PMID: 24659638, PMID: 22150303) and IKZF1 deletions have been observed in pediatric precursor B-cell ALL (PMID: 31076445).|
|Variant||Impact||Protein Effect||Variant Description||Associated with drug Resistance|