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|Synonyms||CVID13 | Hs.54452 | IK1 | IKAROS | LyF-1 | LYF1 | PPP1R92 | PRO0758 | ZNFN1A1|
|Gene Description||IKZF1, IKAROS family zinc finger 1, is a zinc finger transcription factor that regulates hematopoietic differentiation and immune system development, and functions as a tumor suppressor (PMID: 24659638, PMID: 22150303). Mutations in IKZF1 are associated with acute lymphoblastic leukemia (PMID: 24659638, PMID: 22150303) and IKZF1 deletions have been observed in pediatric precursor B-cell ALL (PMID: 31076445).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|IKZF1 del||acute lymphoblastic leukemia||not applicable||N/A||Clinical Study||Prognostic||In multiple clinical studies, including a meta-analysis, IKZF1 deletion was associated with a worse event-free survival and overall survival in patients with acute lymphocytic leukemia (PMID: 25335741, PMID: 26194343, PMID: 27067989).||25335741 26194343 27067989|
|IKZF1 wild-type||multiple myeloma||sensitive||Lenalidomide||Preclinical||Actionable||In a preclinical study, Revlimid (lenalidomide) treatment resulted in IKZF1 degradation and decreased proliferation of multiple myeloma cells in culture (PMID: 24292625).||24292625|