Gene Detail

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Gene Symbol MERTK
Synonyms c-Eyk | c-mer | MER | RP38 | Tyro12
Gene Description MERTK, MER proto-oncogene, tyrosine kinase, binds ligands, LGALS3, TUB, TULP1 and GAS6, to activate downstream signaling pathways including ERK and AKT (PMID: 29554921) and plays a role in phagocytosis of apoptotic cells (PMID: 28369510). MERTK overexpression has been observed in mantle cell lymphoma (PMID: 29554921), glioblastoma multiforme (PMID: 29553850), gastric cancer (PMID: 29285287), and is associated with resistance to Braf inhibition in Braf mutant melanoma (PMID: 29050198).

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Variant Impact Protein Effect Variant Description Associated with drug Resistance
act mut unknown gain of function MERTK act mut indicates that this variant results in a gain of function in the Mertk protein. However, the specific amino acid change has not been identified.
amp none no effect MERTK amplification indicates an increased number of copies of the MERTK gene. However, the mechanism causing the increase is unspecified.
over exp none no effect MERTK over exp indicates an over expression of the Mertk protein and/or mRNA. However, the mechanism causing the over expression is unspecified. Y
positive unknown unknown MERTK positive indicates the presence of the MERTK gene, mRNA, and/or protein.