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Gene Symbol SORBS1
Synonyms CAP | FLAF2 | R85FL | SH3D5 | SH3P12 | SORB1
Gene Description SORBS1, sorbin and SH3 domain containing 1, also known as CAP/ponsin is an adaptor protein that regulates insulin signaling, cell adhesion, and cell motility (PMID: 27791200). Decreased expression in breast cancer may promote tumorigenesis and decreased sensitivity to cisplatin (PMID: 27791200), and an FGFR2-SORBS1 fusion has been reported in intrahepatic cholangiocarcinoma (PMID: 31109923).
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