Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
| Gene Symbol | SORBS1 | ||||||||||
| Synonyms | CAP | FLAF2 | R85FL | SH3D5 | SH3P12 | SORB1 | ||||||||||
| Gene Description | SORBS1, sorbin and SH3 domain containing 1, also known as CAP/ponsin is an adaptor protein that regulates insulin signaling, cell adhesion, and cell motility (PMID: 27791200). Decreased expression in breast cancer may promote tumorigenesis and decreased sensitivity to cisplatin (PMID: 27791200), and an FGFR2-SORBS1 fusion has been reported in intrahepatic cholangiocarcinoma (PMID: 31109923). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
