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Gene Symbol MALT1
Synonyms IMD12 | MLT | MLT1 | PCASP1
Gene Description MALT1, MALT1 paracaspase, regulates nuclear factor kappa B signaling through both scaffolding and proteolytic functions (PMID: 26386283) and may play a role in the allergic response (PMID: 32213560) and in adaptive and innate immune responses (PMID: 31037583). Constitutive activation of Malt1 has been associated with B-cell lymphomas (PMID: 25285878, PMID: 15286744) and promotes tumorigenesis in a variety of tumor types (PMID: 31961340, PMID: 31774199, PMID: 31291468).
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