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Gene Symbol PNRC1
Synonyms B4-2 | PNAS-145 | PROL2 | PRR2
Gene Description PNRC1, proline rich nuclear receptor coactivator 1, acts as a co-activator for nuclear receptors such as SF1, PR, ERR-alpha1, and TR (PMID: 10894149), and is a putative tumor suppressor, playing a role in regulation of ribosomal RNA processing and thereby regulating cell proliferation (PMID: 30373810, PMID: 30455174). PNRC1 copy number loss and decreased gene expression has been identified in several tumor types (PMID: 30373810).
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