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Gene Symbol CHD4
Synonyms CHD-4 | Mi-2b | Mi2-BETA | SIHIWES
Gene Description CHD4, chromodomain helicase DNA binding protein 4, is a subunit of the nucleosome remodeling and histone deacetylase (NuRD) complex, acting as a transcriptional regulator as well as promoting DNA double strand break repair (PMID: 23697937, PMID: 23954449). CHD4 mutations have been identified in endometrial cancer (PMID: 29888111), and increased CHD4 expression has been observed in colorectal cancer (PMID: 28486105) and glioblastoma (PMID: 30872624).
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