Gene Detail


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Gene Symbol CHGA
Synonyms CGA | PHE5 | PHES
Gene Description CHGA, chromogranin A, is a member of the granin protein family expressed by neuroendocrine cells, which is cleaved into multiple peptides, and plays a role in formation of secretory granules, endothelial barrier function, and calcium homeostasis (PMID: 24671122, PMID: 22388654, PMID: 31714338). CHGA level is a biomarker for neuroendocrine tumors (PMID: 24671122, PMID: 22388654) and decreased expression has been observed in early stages of colon cancer (PMID: 31207989), while increased expression has been associated with poor prognosis in prostate cancer (PMID: 31114331).
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