Gene Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at :

Gene Symbol ERLIN2
Synonyms C8orf2 | Erlin-2 | NET32 | SPFH2 | SPG18 | SPG18A | SPG18B
Gene Description ERLIN2, ER lipid raft associated 2, is an endoplasmic reticulum protein that controls intracellular calcium signaling (PMID: 32147972) through ubiquitination of activated inositol 1,4,5-trisphosphate receptors (IP3Rs) (PMID: 30135210), and mediates ER stress response and de novo lipogenesis (PMID: 22681620, PMID: 22690709). ERLIN2 has been identified as a possible oncogene within the amplified, 8p11-8p12, in breast cancer (PMID: 22681620, PMID: 22690709), and may promote metastasis in breast cancer (PMID: 32021278), and a fusion with FGFR1 has been identified in breast cancer (PMID: 23558953).
Additional content available in CKB BOOST