Gene Detail

Gene Symbol CHEK2
Synonyms CDS1 | CHK2 | hCds1 | HuCds1 | LFS2 | PP1425 | RAD53
Gene Description CHEK2, serine/threonine-protein kinase Chk2, is a putative tumor suppressor (PMID: 30562755) required for checkpoint-mediated cell cycle arrest and activation of DNA repair and apoptosis in response to DNA damage (PMID: 28553140). CHEK2 alterations are associated with predisposition to certain human cancers, including breast, prostate, kidney, and colon (PMID: 24880342; PMID: 24713400, PMID: 28553140).
Entrez Id 11200
Chromosome 22
Map Location 22q12.1
Canonical Transcript NM_007194


Additional content available in CKB BOOST