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Gene Symbol AGAP1
Synonyms AGAP-1 | CENTG2 | cnt-g2 | GGAP1
Gene Description AGAP1, ArfGAP with GTPase domain, ankyrin repeat and PH domain 1, encodes a GTPase-activating protein that regulates ADP-ribosylation factor (Arf) activity, interacts with kinesin (PMID: 28430047, PMID: 27531749), and plays a role cytoskeleton maintenance (PMID: 12388557, PMID: 31785816), vesicle trafficking (PMID: 12967569), and dendritic spine morphology (PMID: 27713690). Increased AGAP1 expression has been observed in acute lymphoblastic leukemia (PMID: 20699438), and a fusion with NTRK2 has been identified in glioma (PMID: 33020650).


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