Gene Detail

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Gene Symbol PLEKHA7
Synonyms
Gene Description PLEKHA7, pleckstrin homology domain containing A, localizes to the apical zonula adherens in epithelial cells to inhibit growth through indirect regulation of p120 catenin, CTNNB1 (PMID: 26302406). Decreased expression of PLEKHA7 has been observed in high grade ductal carcinomas and in lobular carcinomas (PMID: 26270346) and a PLEKHA7-ALK fusion has been identified in non-small cell lung cancer (PMID: 29883838).


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