Gene Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at :

Gene Symbol PLEKHA7
Gene Description PLEKHA7, pleckstrin homology domain containing A, localizes to the apical zonula adherens in epithelial cells to inhibit growth through indirect regulation of p120 catenin, CTNNB1 (PMID: 26302406). Decreased expression of PLEKHA7 has been observed in high grade ductal carcinomas and in lobular carcinomas (PMID: 26270346) and a PLEKHA7-ALK fusion has been identified in non-small cell lung cancer (PMID: 29883838).
Additional content available in CKB BOOST