Gene Detail

Gene Symbol PLEKHA7
Gene Description PLEKHA7, pleckstrin homology domain containing A, localizes to the apical zonula adherens in epithelial cells to inhibit growth through indirect regulation of p120 catenin, CTNNB1 (PMID: 26302406). Decreased expression of PLEKHA7 has been observed in high grade ductal carcinomas and in lobular carcinomas (PMID: 26270346) and a fusion with ALK has been identified in non-small cell lung cancer (PMID: 29883838).
Entrez Id 144100
Chromosome 11
Map Location 11p15.2-p15.1
Canonical Transcript NM_175058

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