Gene Detail

Gene Symbol PLEKHA7
Gene Description PLEKHA7, pleckstrin homology domain containing, family A member 7, localizes to the apical zonula adherens in epithelial cells to inhibit growth through indirect regulation of p120 catenin, CTNNB1 (PMID: 26302406). Decreased expression of PLEKHA7 has been observed in high grade ductal carcinomas and in lobular carcinomas (PMID: 26270346) and a fusion with ALK has been identified in non-small cell lung cancer (PMID: 29883838).
Entrez Id 144100
Chromosome 11
Map Location 11p15.2-p15.1
Canonical Transcript

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