Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol CUX1
Synonyms CASP | CDP | CDP/Cut | CDP1 | Clox | COY1 | CUTL1 | CUX | Cux/CDP | GDDI | GOLIM6 | Nbla10317 | p100 | p110 | p200 | p75
Gene Description CUX1, cut like homeobox 1, is a transcription factor, that may act as a transcriptional repressor or an activator (PMID: 32547943), is required for cell motility (PMID: 22306263), and plays a role in cell cycle progression, cell proliferation, and DNA repair (PMID: 28147323). CUX1 fusions with BRAF have been observed in solid tumors (PMID: 25190083, PMID: 26314551), with FGFR1 in hematological tumors (PMID: 21330321), and with ALK in NSCLC (PMID: 30010043), and altered Cux1 expression may play a role in castrate resistant prostate cancer (PMID: 32180898).


Additional content available in CKB BOOST