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Gene Symbol CYP17A1
Synonyms CPT7 | CYP17 | P450C17 | S17AH
Gene Description CYP17A1, cytochrome P450 family 17 subfamily A member 1, is an enzyme that catalyzes the addition of a hydroxyl group to pregnenolone and progesterone, and cleaves the hydroxylated intermediates to synthesize androgens and corticoids (PMID: 29372682, PMID: 21051590, PMID: 27748439). Overexpression of CYP17A1 is associated with poor prognosis in glioma (PMID: 28530704).


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