Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
| Gene Symbol | DAB2 | ||||||||||
| Synonyms | DOC-2 | DOC2 | ||||||||||
| Gene Description | DAB2, DAB adaptor protein 2, encodes for a phosphoprotein that activates upon binding to other proteins, and is found to play a role in stem cell differentiation, cell arrangement, cytoskeleton assembly, and epithelial-mesenchymal transition (PMID: 24638085). DAB2, described as a tumor suppressor, has been found to be deleted or methylated, resulting in decreased expression, in ovarian cancer, breast cancer, and nasopharyngeal carcinoma (PMID: 17115114, PMID: 20525238), while overexpression in urothelial carcinoma of the bladder has been associated with poor prognosis (PMID: 31968685). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
