Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol DCTN1
Synonyms DAP-150 | DP-150 | P135
Gene Description DCTN1, dynactin subunit 1, is one of six subunits and the largest subunit of the dynactin complex (PMID: 30510450), which regulates the motor function of the dynein complex during axonal trasnport (PMID: 31291987). DCTN1-ALK fusions have been identified in uterine inflammatory myofibroblastic tumors (PMID: 26062823), lung cancer (PMID: 28970558), and non-neural granular cell tumors (PMID: 30001233), and decreased expression of Dctn1 has been observed in melanoma (PMID: 29864111).


Additional content available in CKB BOOST