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|Synonyms||CAP-Rf | DBX | DDX14 | DDX3 | HLP2 | MRX102 | MRXSSB|
|Gene Description||DDX3X, DEAD-box helicase 3 X-linked, is a member of the DEAD-box RNA helicase family and plays a role in several cellular processes including mRNA metabolism (PMID: 31906196), translation initiation, cell-cycle regulation, and cell survival (PMID: 26541825, PMID: 27180681), and functions in brain cortical development (PMID: 32135084). DDX3X mutations have been demonstrated in several tumor types, including leukemia and medulloblastoma (PMID: 26541825, PMID: 27180681), and overexpression has been observed in several solid tumors, including pancreatic ductal adenocarcinoma (PMID: 31906196), while decreased expression has been observed in other tumor types, including uveal melanoma and diffuse large B-cell lymphoma (PMID: 31906196).|