Gene Detail
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| Gene Symbol | DDX10 | ||||||||||
| Synonyms | Dbp4 | HRH-J8 | ||||||||||
| Gene Description | DDX10, DEAD-box helicase 10, is a member of the DEAD-box family of RNA helicases and plays a role in protein synthesis, ribosomal biogenesis, and regulation of pathways involved in cell proliferation and migration, including the MAPK and AKT pathways (PMID: 30738579, PMID: 26713367, PMID: 8660968). An NUP98-DDX10 fusion has been identified in acute myeloid leukemia (PMID: 32344427), and both increased and decreased expression of DDX10 has been identified in several tumor types, including overexpression in osteosarcoma and lung adenocarcinoma (PMID: 30738579, PMID: 33973712), and reduced expression in ovarian cancer (PMID: 26713367). | ||||||||||
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