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Gene Symbol DTX1
Synonyms hDx-1 | RNF140
Gene Description DTX1, deltex E3 ubiquitin ligase 1, encodes a protein that is a transcriptional target of Notch1 and regulator of Notch signaling via E3 ubiquitin ligase activity either directly or potentially indirectly with other protein substrates that target Notch1, resulting in Notch1 degradation (PMID: 29440432, PMID: 16284625), and has been shown to play a role in neural differentiation (PMID: 26714454, PMID: 11564735). DTX1 mutations have been identified in diffuse large B-cell lymphoma (PMID: 28183850, PMID: 25171927).
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