Gene Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at :

Gene Symbol ENG
Synonyms END | HHT1 | ORW1
Gene Description ENG, endoglin, also known as CD105 (PMID: 32132043), is a membrane coreceptor for the TGFbeta superfamily (PMID: 31897911) and is preferentially expressed in proliferating endothelial cells (PMID: 18381930) and functions in angiogenesis and leukocyte trafficking (PMID: 32059544). Expression of Eng has been identified in multiple tumors and is associated with poor clinical outcomes (PMID: 18381930), and lower levels of soluble Eng has been associated with high-grade prostate cancer (PMID: 32132043).
Additional content available in CKB BOOST