Gene Detail

Gene Symbol EPHB4
Synonyms CMAVM2 | HFASD | HTK | LMPHM7 | MYK1 | TYRO11
Gene Description EPHB4, EPH receptor B4, encodes for a a receptor tyrosine kinase, which upon ligand binding can result in bidirectional signaling between cells (PMID: 12094214). Amplification and aberrant expression of EPHB4 has been demonstrated in several tumor types including breast cancer and lung cancer, and is associated with cancer cell survival (PMID: 16816380, PMID: 26073592).
Entrez Id 2050
Chromosome 7
Map Location 7q22.1
Canonical Transcript NM_004444

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