Gene Detail

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Gene Symbol EPHB4
Synonyms CMAVM2 | HFASD | HTK | LMPHM7 | MYK1 | TYRO11
Gene Description EPHB4, EPH receptor B4, encodes for an erythroprotein-producing hepatoma (Eph) receptor tyrosine kinase, which upon ligand binding results in bidirectional signaling between cells (PMID: 12094214). Amplification and/or overexpression of EPHB4 have been observed in several tumor types including breast cancer (PMID: 16816380), lung cancer (PMID: 31934189), esophageal squamous cell cancer (PMID: 31885720), and may promote cancer cell survival (PMID: 26073592).


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