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Gene Symbol EPS15
Synonyms AF-1P | AF1P | MLLT5
Gene Description EPS15, epidermal growth factor receptor pathway substrate 15, is a putative dynamin-homolog that functions in recycling of endosomes from the plasma membrane (PMID: 32041776) and includes recycling of the EGFR receptor (PMID: 30214560). An EPS15-BRAF fusion has been identified in lung adenocarcinoma (PMID: 26314551), while Eps15 expression may play a role in angiogenesis in non-small cell lung cancer (PMID: 31023336) and overexpression in osteosarcoma has been associated with decreased survival (PMID: 30975166).
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