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|Synonyms||c-ERB-2 | c-ERB2 | CD340 | HER-2 | HER-2/neu | HER2 | MLN 19 | NEU | NGL | TKR1 | VSCN2|
|Gene Description||ERBB2 (HER2), erb-b2 receptor tyrosine kinase 2, is an EGFR receptor tyrosine kinase that activates PI3K-AKT-mTOR and RAS-RAF-MEK-ERK pathways, therefore regulating growth and transformation (PMID: 17471238). ERBB2 (HER2) amplification and/or overexpression, and activation has been implicated in several tumor types (PMID: 17471238, PMID: 31019892), and is commonly observed in breast cancer (PMID: 31650186, PMID: 32161378), while some ERBB2 mutations have been implicated in resistance to select tyrosine kinase inhibitors (PMID: 32327210).|