Gene Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at :

Gene Symbol ERBB2
Synonyms c-ERB-2 | c-ERB2 | CD340 | HER-2 | HER-2/neu | HER2 | MLN 19 | MLN-19 | NEU | NGL | p185(erbB2) | TKR1 | VSCN2
Gene Description ERBB2 (HER2), erb-b2 receptor tyrosine kinase 2, is an EGFR receptor tyrosine kinase that activates PI3K-AKT-mTOR and RAS-RAF-MEK-ERK pathways, therefore regulating growth and transformation (PMID: 17471238). ERBB2 (HER2) amplification and/or overexpression, and activation has been implicated in several tumor types (PMID: 17471238, PMID: 31019892), and is commonly observed in breast cancer (PMID: 31650186, PMID: 32161378), while some ERBB2 mutations have been implicated in resistance to select tyrosine kinase inhibitors (PMID: 32327210).
Additional content available in CKB BOOST