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|Synonyms||ALS19 | HER4 | p180erbB4|
|Gene Description||ERBB4, erb-b2 receptor tyrosine kinase 4, encodes HER4, an ERBB family member that plays a role in cell survival and differentiation (PMID: 12648466). ERBB4 activating mutations are frequent in melanoma and have been demonstrated in lung adenocarcinoma (PMID: 19718025, PMID: 26050618).|
|Variant||Impact||Protein Effect||Variant Description||Associated with drug Resistance|
|act mut||unknown||gain of function||ERBB4 (HER4) act mut indicates that this variant results in a gain of function in the Erbb4 (Her4) protein. However, the specific amino acid change has not been identified.|
|inact mut||unknown||loss of function||ERBB4 inact mut indicates that this variant results in a loss of function of the Erbb4 protein. However, the specific amino acid change has not been identified.|
|mutant||unknown||unknown||ERBB4 mutant indicates an unspecified mutation in the ERBB4 gene.|