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Gene Symbol ERBB4
Synonyms ALS19 | HER4 | p180erbB4
Gene Description ERBB4, erb-b2 receptor tyrosine kinase 4, encodes HER4, an ERBB family member that plays a role in cell survival and differentiation (PMID: 12648466). ERBB4 activating mutations are frequent in melanoma and have been demonstrated in lung adenocarcinoma (PMID: 19718025, PMID: 26050618).

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Molecular Profile Protein Effect Treatment Approaches
ERBB4 A1083V unknown
ERBB4 A1130S unknown
ERBB4 A1136D unknown
ERBB4 A455T unknown
ERBB4 A672D unknown
ERBB4 A828D unknown
ERBB4 A845V unknown
ERBB4 A877S unknown
ERBB4 A888T unknown
ERBB4 act mut gain of function Lapatinib
ERBB4 amp no effect
ERBB4 C217R unknown
ERBB4 C234Y unknown
ERBB4 C293F unknown
ERBB4 C304F unknown
ERBB4 C56Y unknown
ERBB4 C589F unknown
ERBB4 C589R unknown
ERBB4 C593F unknown
ERBB4 C803S unknown
ERBB4 D1104Y unknown
ERBB4 D245G no effect
ERBB4 D335N unknown
ERBB4 D518G unknown
ERBB4 D595V gain of function Lapatinib
ERBB4 D609N unknown
ERBB4 D931Y gain of function Lapatinib
ERBB4 D991N unknown
ERBB4 E1121D unknown
ERBB4 E1144* unknown
ERBB4 E317K gain of function Lapatinib
ERBB4 E387D unknown
ERBB4 E397A unknown
ERBB4 E452K gain of function Lapatinib
ERBB4 E542K gain of function Lapatinib
ERBB4 E560K unknown
ERBB4 E563K gain of function Lapatinib
ERBB4 E57K no effect
ERBB4 E57V unknown
ERBB4 E693D unknown
ERBB4 E836K gain of function Lapatinib
ERBB4 E872K gain of function Lapatinib
ERBB4 E874* unknown
ERBB4 E928* unknown
ERBB4 E934K unknown
ERBB4 F1003L unknown
ERBB4 F1267L unknown
ERBB4 F252L unknown
ERBB4 G107V unknown
ERBB4 G1109C gain of function Lapatinib
ERBB4 G130E unknown
ERBB4 G456E unknown
ERBB4 G516V unknown
ERBB4 G516W unknown
ERBB4 G727D unknown
ERBB4 G880R unknown
ERBB4 G907E unknown
ERBB4 G917V unknown
ERBB4 G936R gain of function - predicted Lapatinib
ERBB4 H295Q unknown
ERBB4 H618P no effect - predicted
ERBB4 H841Q unknown
ERBB4 I161M unknown
ERBB4 I166N unknown
ERBB4 I658F unknown
ERBB4 I771T unknown
ERBB4 I827R unknown
ERBB4 inact mut loss of function
ERBB4 K1002N unknown
ERBB4 K1291N unknown
ERBB4 K751M loss of function
ERBB4 K751Q unknown
ERBB4 K751T unknown
ERBB4 K812N unknown
ERBB4 K935I gain of function Lapatinib
ERBB4 L1008V unknown
ERBB4 L134P unknown
ERBB4 L155F unknown
ERBB4 L369I unknown
ERBB4 L420M unknown
ERBB4 L521M unknown
ERBB4 L694V unknown
ERBB4 L864P unknown
ERBB4 M250I unknown
ERBB4 M313I unknown
ERBB4 M882I unknown
ERBB4 mutant unknown
ERBB4 N1044D unknown
ERBB4 N181S gain of function - predicted Lapatinib
ERBB4 N352S unknown
ERBB4 N855K unknown
ERBB4 over exp no effect
ERBB4 P1033S gain of function - predicted
ERBB4 P1116L unknown
ERBB4 P224L unknown
ERBB4 P377R gain of function
ERBB4 P386Q unknown
ERBB4 P594Q unknown
ERBB4 P619L unknown
ERBB4 P697S unknown
ERBB4 P920R unknown
ERBB4 Q44E unknown
ERBB4 Q941* unknown
ERBB4 R106C unknown
ERBB4 R1139L unknown
ERBB4 R168W unknown
ERBB4 R196C unknown
ERBB4 R306S gain of function - predicted Lapatinib
ERBB4 R393W unknown
ERBB4 R488W unknown
ERBB4 R50C unknown
ERBB4 R524C unknown
ERBB4 R525S unknown
ERBB4 R544W gain of function Lapatinib
ERBB4 R711C unknown
ERBB4 R711L unknown
ERBB4 R81* loss of function - predicted
ERBB4 R842Q unknown
ERBB4 R95C unknown
ERBB4 R992C unknown
ERBB4 S1043L unknown
ERBB4 S303Y unknown
ERBB4 S341L unknown
ERBB4 S479I unknown
ERBB4 S774G unknown
ERBB4 T1110I unknown
ERBB4 T140I unknown
ERBB4 T19A unknown
ERBB4 T244R no effect - predicted
ERBB4 T480fs loss of function - predicted
ERBB4 T731M unknown
ERBB4 T898S unknown
ERBB4 T915S unknown
ERBB4 V212G unknown
ERBB4 V348L no effect - predicted
ERBB4 V391I gain of function
ERBB4 V421L unknown
ERBB4 V59D unknown
ERBB4 V732F unknown
ERBB4 V903F unknown
ERBB4 W171* loss of function - predicted
ERBB4 W823C unknown
ERBB4 wild-type no effect
ERBB4 Y111H unknown
ERBB4 Y1301C unknown
ERBB4 Y285C gain of function Lapatinib