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Gene Symbol | ERBB4 | ||||||||||
Synonyms | ALS19 | HER4 | p180erbB4 | ||||||||||
Gene Description | ERBB4, erb-b2 receptor tyrosine kinase 4, encodes HER4, an ERBB family member that plays a role in cell survival and differentiation (PMID: 12648466). ERBB4 activating mutations are frequent in melanoma and have been demonstrated in lung adenocarcinoma (PMID: 19718025, PMID: 26050618). | ||||||||||
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Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
ERBB4 A1083V | unknown | |
ERBB4 A1130S | unknown | |
ERBB4 A1136D | unknown | |
ERBB4 A17V | no effect - predicted | |
ERBB4 A455T | unknown | |
ERBB4 A672D | unknown | |
ERBB4 A828D | unknown | |
ERBB4 A845V | unknown | |
ERBB4 A877S | unknown | |
ERBB4 A888T | unknown | |
ERBB4 act mut | gain of function | Lapatinib |
ERBB4 amp | no effect | |
ERBB4 C217R | unknown | |
ERBB4 C234Y | unknown | |
ERBB4 C293F | unknown | |
ERBB4 C304F | unknown | |
ERBB4 C56Y | unknown | |
ERBB4 C589F | unknown | |
ERBB4 C589R | unknown | |
ERBB4 C593F | unknown | |
ERBB4 C803S | unknown | |
ERBB4 D1104Y | unknown | |
ERBB4 D245G | no effect | |
ERBB4 D335N | unknown | |
ERBB4 D518G | unknown | |
ERBB4 D595V | gain of function | Lapatinib |
ERBB4 D609N | unknown | |
ERBB4 D767V | no effect - predicted | |
ERBB4 D931Y | gain of function | Lapatinib |
ERBB4 D991N | unknown | |
ERBB4 E1011* | no effect - predicted | |
ERBB4 E1121D | unknown | |
ERBB4 E1144* | unknown | |
ERBB4 E317K | gain of function | Lapatinib |
ERBB4 E387D | unknown | |
ERBB4 E397A | unknown | |
ERBB4 E452K | gain of function | Lapatinib |
ERBB4 E542K | gain of function | Lapatinib |
ERBB4 E560K | unknown | |
ERBB4 E563K | gain of function | Lapatinib |
ERBB4 E57K | no effect | |
ERBB4 E57V | unknown | |
ERBB4 E693D | unknown | |
ERBB4 E715K | gain of function | |
ERBB4 E836K | gain of function | Lapatinib |
ERBB4 E872K | gain of function | Lapatinib |
ERBB4 E874* | unknown | |
ERBB4 E890Q | no effect - predicted | |
ERBB4 E928* | unknown | |
ERBB4 E934K | unknown | |
ERBB4 F1003L | unknown | |
ERBB4 F1102C | unknown | |
ERBB4 F1267L | unknown | |
ERBB4 F252L | unknown | |
ERBB4 fusion | unknown | |
ERBB4 G107V | unknown | |
ERBB4 G1096I | no effect - predicted | |
ERBB4 G1109C | gain of function | Lapatinib |
ERBB4 G130E | unknown | |
ERBB4 G456E | unknown | |
ERBB4 G516V | unknown | |
ERBB4 G516W | unknown | |
ERBB4 G668V | no effect - predicted | |
ERBB4 G727D | unknown | |
ERBB4 G741R | gain of function - predicted | |
ERBB4 G802D | gain of function | |
ERBB4 G863E | loss of function | |
ERBB4 G880R | unknown | |
ERBB4 G907E | unknown | |
ERBB4 G917V | unknown | |
ERBB4 G936R | no effect | |
ERBB4 H190Y | unknown | |
ERBB4 H295Q | unknown | |
ERBB4 H618P | no effect - predicted | |
ERBB4 H841Q | unknown | |
ERBB4 I1226V | no effect - predicted | |
ERBB4 I161M | unknown | |
ERBB4 I166N | unknown | |
ERBB4 I658F | unknown | |
ERBB4 I771T | unknown | |
ERBB4 I815N | no effect - predicted | |
ERBB4 I827R | unknown | |
ERBB4 I959T | no effect - predicted | |
ERBB4 inact mut | loss of function | |
ERBB4 K1002N | unknown | |
ERBB4 K1002R | unknown | |
ERBB4 K1002T | unknown | |
ERBB4 K1223M | unknown | |
ERBB4 K1223R | unknown | |
ERBB4 K1223T | unknown | |
ERBB4 K1291N | unknown | |
ERBB4 K751M | loss of function | |
ERBB4 K751Q | unknown | |
ERBB4 K751T | unknown | |
ERBB4 K812N | unknown | |
ERBB4 K935I | gain of function | Lapatinib |
ERBB4 L1008V | unknown | |
ERBB4 L134P | unknown | |
ERBB4 L155F | unknown | |
ERBB4 L369I | unknown | |
ERBB4 L420M | unknown | |
ERBB4 L521M | unknown | |
ERBB4 L694V | unknown | |
ERBB4 L780P | loss of function | |
ERBB4 L798H | unknown | |
ERBB4 L798P | unknown | |
ERBB4 L798R | unknown | |
ERBB4 L864P | unknown | |
ERBB4 M250I | unknown | |
ERBB4 M313I | unknown | |
ERBB4 M882I | unknown | |
ERBB4 M993I | gain of function - predicted | |
ERBB4 mutant | unknown | |
ERBB4 N1044D | unknown | |
ERBB4 N181S | gain of function - predicted | Lapatinib |
ERBB4 N280I | unknown | |
ERBB4 N352S | unknown | |
ERBB4 N855K | unknown | |
ERBB4 over exp | no effect | |
ERBB4 P1033S | gain of function - predicted | |
ERBB4 P1116L | unknown | |
ERBB4 P224L | unknown | |
ERBB4 P377R | gain of function | |
ERBB4 P386Q | unknown | |
ERBB4 P594Q | unknown | |
ERBB4 P619L | unknown | |
ERBB4 P697S | unknown | |
ERBB4 P920R | unknown | |
ERBB4 positive | unknown | |
ERBB4 Q44E | unknown | |
ERBB4 Q707E | unknown | |
ERBB4 Q941* | unknown | |
ERBB4 R106C | unknown | |
ERBB4 R1139L | unknown | |
ERBB4 R168W | unknown | |
ERBB4 R196C | unknown | |
ERBB4 R220I | no effect - predicted | |
ERBB4 R306S | gain of function - predicted | Lapatinib |
ERBB4 R393W | unknown | |
ERBB4 R488W | unknown | |
ERBB4 R50C | unknown | |
ERBB4 R524C | unknown | |
ERBB4 R525S | unknown | |
ERBB4 R544W | gain of function | Lapatinib |
ERBB4 R687K | gain of function | |
ERBB4 R711C | unknown | |
ERBB4 R711L | unknown | |
ERBB4 R81* | loss of function - predicted | |
ERBB4 R842Q | unknown | |
ERBB4 R847H | unknown | |
ERBB4 R95C | unknown | |
ERBB4 R992C | unknown | |
ERBB4 S1043L | unknown | |
ERBB4 S1289A | unknown | |
ERBB4 S303Y | unknown | |
ERBB4 S341L | unknown | |
ERBB4 S479I | unknown | |
ERBB4 S774G | unknown | |
ERBB4 S774N | unknown | |
ERBB4 S774R | unknown | |
ERBB4 T1110I | unknown | |
ERBB4 T140I | unknown | |
ERBB4 T19A | unknown | |
ERBB4 T244R | no effect - predicted | |
ERBB4 T480fs | loss of function - predicted | |
ERBB4 T731M | no effect - predicted | |
ERBB4 T898S | unknown | |
ERBB4 T915S | unknown | |
ERBB4 V212G | unknown | |
ERBB4 V348L | no effect - predicted | |
ERBB4 V391I | gain of function | |
ERBB4 V421L | unknown | |
ERBB4 V59D | unknown | |
ERBB4 V673F | no effect - predicted | |
ERBB4 V732F | unknown | |
ERBB4 V903F | unknown | |
ERBB4 V952F | no effect - predicted | |
ERBB4 W171* | loss of function - predicted | |
ERBB4 W823C | unknown | |
ERBB4 wild-type | no effect | |
ERBB4 Y111H | unknown | |
ERBB4 Y1301C | unknown | |
ERBB4 Y285C | gain of function | Lapatinib |