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|Synonyms||BTF2 | GTF2H | RAD25 | TFIIH | TTD2 | XPB|
|Gene Description||ERCC3, TFIIH basal transcription factor complex helicase XPB subunit, is an ATP-dependent 5’-3’ DNA helicase that plays a role in nucleotide excision repair and RNA transcription (PMID: 8157004). An ERCC3 nonsense mutation is associated with breast cancer risk (PMID: 27655433) and ERCC3 mRNA expression is correlated with poor prognosis in pancreatic ductal adenocarcinoma (PMID: 27384421).|