Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol AKT2
Synonyms HIHGHH | PKBB | PKBBETA | PRKBB | RAC-BETA
Gene Description AKT2, RAC-beta serine/threonine-protein kinase, regulates a number of cell functions, including proliferation, survival, growth, angiogenesis, and metabolism through PI3K signaling (PMID: 28557977). Amplification and overexpression of Akt2 has been identified in a variety of solid tumor types (PMID: 7657393, PMID: 29199386, PMID: 29374601) and is downregulated by several micro-RNAs to inhibit cell migration and invasion (PMID: 28586057, PMID: 28548936, PMID: 28534950).


Additional content available in CKB BOOST