Gene Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at :

Gene Symbol ERN1
Synonyms hIRE1p | IRE1 | IRE1a | IRE1P
Gene Description ERN1, endoplasmic reticulum to nucleus signaling 1, is a serine/threonine kinase and an endoribonuclease, which regulates the unfolded protein response pathway, and plays a role in mRNA splicing, innate immunity, and cellular homeostasis (PMID: 29747876, PMID: 11175748). Mutations in ERN1 has been identified in glioblastoma (PMID: 29311133), and expression of ERN1 has been identified in lung adenocarcinoma (PMID: 28334878).
Additional content available in CKB BOOST