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|Synonyms||hIRE1p | IRE1 | IRE1a | IRE1P|
|Gene Description||ERN1, endoplasmic reticulum to nucleus signaling 1, is a serine/threonine kinase and an endoribonuclease, which regulates the unfolded protein response pathway, and plays a role in mRNA splicing, innate immunity, and cellular homeostasis (PMID: 29747876, PMID: 11175748). Mutations in ERN1 has been identified in glioblastoma (PMID: 29311133), and expression of ERN1 has been identified in lung adenocarcinoma (PMID: 28334878).|