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Gene Symbol FGFR4
Synonyms CD334 | JTK2 | TKF
Gene Description FGFR4, fibroblast growth factor receptor 4, is a receptor tyrosine kinase activated upon binding of the FGF19 ligand, which then activates RAS-MAPK, PI3K-AKT, and STAT pathways, and functions in embryonic development and tissue repair (PMID: 22508544, PMID: 32154250). Overexpression of Fgfr4 has been observed in colorectal cancer (PMID: 32236572), hepatocellular carcinoma, breast cancer, oropharyngeal squamous cell carcinoma, and pancreatic cancer (PMID: 32154250) and FGFR4 mutations have been reported in gastric cancer (PMID: 31601997) and may also confer resistance to FGFR inhibitors (PMID: 31575540).


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