Gene Detail


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Gene Symbol KDM2A
Synonyms CXXC8 | FBL11 | FBL7 | FBXL11 | JHDM1A | LILINA
Gene Description KDM2A, lysine demethylase 2A, is a histone demethylase responsible for maintaining centromere integrity, influencing histone modification, and regulating chromatin remodeling to activate or repress gene transcription (PMID: 19001877, PMID: 30059280). Overexpression, amplification, and Kdm1a function have been associated with proliferation of lung cancer cells (PMID: 24482232), breast cancer progression (PMID: 26207617), and inhibition of Tet2 in TNBC (PMID: 28785073).
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