Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Synonyms||CXXC8 | FBL11 | FBL7 | FBXL11 | JHDM1A | LILINA|
|Gene Description||KDM2A, lysine (K)-specific demethylase 2A, is a histone demethylase responsible for maintaining centromere integrity, influencing histone modification, and affecting chromatin remodeling to activate or repress gene transcription (PMID: 19001877). Overexpression, amplification, and Kdm1a function has been associated with proliferation of lung cancer cells (PMID: 24482232), breast cancer progression (PMID: 26207617), and inhibition of Tet2 in TNBC (PMID: 28785073), respectively.|