Gene Detail
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| Gene Symbol | FOXO1 | ||||||||||
| Synonyms | FKH1 | FKHR | FOXO1A | ||||||||||
| Gene Description | FOXO1, forkhead box O1, encodes for a protein belonging to the family of forkhead box O transcription factors, which plays a role in multiple cellular processes including cell cycle arrest, apoptosis, and prevention of reactive oxygen species (PMID: 18715783). FOXO1 fusions are frequently observed in alveolar rhabdomyosarcoma (PMID: 24334454), including FOXO1-FGFR1 (PMID: 21666686), PAX3-FOXO1 (PMID: 24334454), and PAX7-FOXO1 (PMID: 12865925, PMID: 8187070). | ||||||||||
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