Gene Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at :

Gene Symbol SIRT1
Synonyms SIR2 | SIR2alpha | SIR2L1
Gene Description SIRT1, sirtuin 1, is an NAD+ dependent histone deacetylase that plays a role in metabolism, cell survival, and cell signaling (PMID: 26481524, PMID: 24020000). SIRT1 expression is dysregulated in several tumor types, including leukemia, prostate, colon, and pancreatic, and gastric cancer (PMID: 26655844, PMID: 19244112, PMID: 30710340).
Additional content available in CKB BOOST