Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
| Gene Symbol | GPR161 | ||||||||||
| Synonyms | RE2 | ||||||||||
| Gene Description | GPR161, G protein-coupled receptor 161, is a member of the class A rhodopsin family that regulates sonic hedgehog (Shh) signaling and plays a role in development (PMID: 24599592, PMID: 29438014). Germline GPR161 mutations may be a risk factor for pediatric medulloblastoma (PMID: 31609649) and overexpression of Gpr161 has been observed to promote cell proliferation and migration in breast cancer (PMID: 24599592). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
