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Gene Symbol GPR161
Synonyms RE2
Gene Description GPR161, G protein-coupled receptor 161, is a member of the class A rhodopsin family that regulates sonic hedgehog (Shh) signaling and plays a role in development (PMID: 24599592, PMID: 29438014). Germline GPR161 mutations may be a risk factor for pediatric medulloblastoma (PMID: 31609649) and overexpression of Gpr161 has been observed to promote cell proliferation and migration in breast cancer (PMID: 24599592).
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